SynthesisTechnology in cancer research & treatment
Effect of Perioperative Glutamine-Enhanced Parenteral Nutrition on Short-Term Outcomes in Colorectal Cancer Patients Undergoing Radical Resection: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Synthesis in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundParenteral glutamine (Gln) supplementation can enhance the immune function of patients with colorectal cancer(CRC), regulate inflammatory response, nitrogen balance and protein synthesis, reduce the morbidity of postoperative complications and shorten the length of hospitalization. However, some guidelines and clinical studies have questioned the rationality of using glutamine-containing immunonutrition support in the perioperative period of CRC. Therefore, we conducted a meta-analysis of the effects of perioperative glutamine-enriched parenteral nutrition on short-term postoperative clinical outcomes in patients with CRC.MethodsA comprehensive search of all relevant literature from the default date to June 2025 was performed using the following databases: PubMed, Embase, Web of Science, Cochrane Library, China Biology Medicine Database (CBM), China National Knowledge Infrastructure (CNKI), VIP Medical Information System (VIP), and Wanfang electronic database. RevMan 5.3 software was used for the meta-analysis. We calculated the outcomes using random- and fixed-effects models.ResultsSeventeen single-center randomized controlled trials (RCTs) involving 950 patients with CRC were included. The control group consisted of 470 patients who received traditional parenteral nutrition therapy and the experimental group consisted of 480 patients who received parenteral nutrition with Gln. The analyses showed that perioperative Gln-enhanced parenteral nutrition reduced the morbidity of infectious complications (Relative Risk [RR]=0.36,95% Confidence Interval [CI]:0.23-0.58) and non-infectious complications (RR=0.27, 95% CI: 0.13-0.55). The length of hospitalization was reduced by 2.18 days (mean difference [MD] = -2.18, 95% CI: -2.59--1.78).ConclusionParenteral Gln supplementation may potentially reduced the morbidity of postoperative complications, shortened postoperative hospitalization, improved some aspects of nutritional status, immune and inflammation function in patients with CRC, based on current evidence of low-to-moderate certainty.
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