ArticleThe Journal of organic chemistry2026
Synthesis of Sulfated Glycomimetics with Micromolar Affinity for Midkine.
Article in The Journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A series of sulfated oligosaccharides (one tetra- and ten disaccharides) have been synthesized to study their interactions with midkine, a heparin-binding growth factor involved in cancer and inflammation. These compounds were prepared as glycosaminoglycan (GAG) mimetics and displayed hydrophobic groups at specific positions to enhance midkine binding. For the synthesis of the tetrasaccharide, a fluoro-assisted strategy was adopted. The use of an
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