Evidence map›Paper›PMID 41891750›Full record

ArticlemBio2026

Structural and functional analysis of the

Yunfeng Li, Giannina Ow-Young-Villarreal, Yulia Pustovalova, David M D Bailey, Joshua Yarrow, George Korza, Faith Ye, Heidi Erlandsen, Peter Setlow, Graham Christie and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yunfeng Li *Department of Molecular Biology and Biophysics, UConn Health, Farmington, Connecticut, USA.
Giannina Ow-Young-Villarreal *Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom.ORCID 0009-0008-0350-1253
Yulia PustovalovaDepartment of Molecular Biology and Biophysics, UConn Health, Farmington, Connecticut, USA.ORCID 0000-0003-3024-1764
David M D BaileyDepartment of Zoology, University of Cambridge, Cambridge, United Kingdom.
Joshua YarrowDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom.
George KorzaDepartment of Molecular Biology and Biophysics, UConn Health, Farmington, Connecticut, USA.
Faith YeDepartment of Molecular Biology and Biophysics, UConn Health, Farmington, Connecticut, USA.
Heidi ErlandsenDepartment of Pharmaceutical Science, University of Connecticut, Storrs, Connecticut, USA.
Peter SetlowDepartment of Molecular Biology and Biophysics, UConn Health, Farmington, Connecticut, USA.ORCID 0000-0003-3119-2669
Graham ChristieDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-7177-9646
Bing HaoDepartment of Molecular Biology and Biophysics, UConn Health, Farmington, Connecticut, USA.ORCID 0000-0003-3029-5340

Funding

Substrate targeting mechanism of a DesCEND pathwayR01GM135592 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HAO, BING · 2020 to 2023
$1.9M
Molecular mechanism of the synapse organizer C1QL3R21NS142751 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Bing Hao · 2025 to 2026
$458k
NIGMS NIH HHS GM135592NIGMS NIH HHS R01 GM135592NINDS NIH HHS NS131664NINDS NIH HHS R21 NS142751US Army Research Office 76316-LS
6 · The paper itself

Abstract

Bacterial endospores are metabolically dormant yet can rapidly return to vegetative growth upon exposure to nutrients through the process of germination. Spore germination is triggered by specific chemical nutrients binding to cognate germinant receptors (GRs) in spores' inner membrane. These GRs function as ligand-gated ion channels and are composed of clusters of at least three subunits. Given their central role in germinant recognition and discrimination, elucidating 3D structures of GR subunits is a key part of efforts to understand the mechanism(s) of spore germination. Here, we present the crystal structure of the N-terminal domain of the IMPORTANCE: Many bacteria in the order

Indexed as

Bacillus cereusBacterial ProteinsInosineSpores, BacterialCrystallography, X-RayModels, MolecularMutagenesis, Site-DirectedProtein BindingProtein ConformationBacterial ProteinsInosineBacillusBacillus cereusgerminant receptorspore germinationstructural biology

Identifiers

PMID41891750
PMCPMC13170314

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.