SynthesisPacing and clinical electrophysiology : PACE2026
Hemolysis and Renal Outcomes After Pulsed Field Versus Thermal Ablation for Atrial Fibrillation: A Meta-Analysis.
Synthesis in Pacing and clinical electrophysiology : PACE, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
purposeEvaluate the comparative risk of hemolysis and acute kidney injury (AKI) with pulsed field ablation (PFA) versus thermal ablation (TA) for atrial fibrillation.
methodsDatabases were searched through June 2025 for comparative studies reporting hemolysis markers or renal outcomes. Random-effects models estimated risk ratios (RRs) and mean differences (MDs).
resultsEight studies (n = 4307) were included. Compared with TA, PFA was not associated with a statistically significant increase in AKI (RR 2.00, 95% CI 0.5-7.9) or change in creatinine (MD 0.02 mg/dL, p = 0.10). PFA was associated with higher LDH (MD +72 U/L p < 0.001) and lower haptoglobin (MD -0.60 g/L p < 0.001).
conclusionsPFA may be associated with greater biochemical hemolysis than TA; however, no statistically significant difference in AKI or post-procedural creatinine was observed in pooled analyses.
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