ArticleAIDS (London, England)2026
Age and viral replication, not vertical HIV acquisition, drive inflammation and T-cell dysfunction in heavily treatment experienced: data from the Prestigio Registry.
Article in AIDS (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Heavily treatment-experienced (HTE) individuals carry a high inflammatory burden, which is potentially increased in those with vertical HIV transmission (VT), due to lifelong viral exposure. We assessed inflammation and T-cell activation/exhaustion/senescence in HTE with VT or horizontal transmission (HT). Interleukin-6 (IL-6) was lower in VT and positively correlated with age. T-cell dysfunction was greater in HTE than people without HIV (PWOH), mainly driven by viremic VT and HT. Age and viral replication, rather than transmission mode, underlie immune dysregulation in HTE.
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