Evidence map›Paper›PMID 41891186›Full record

ArticleMicrobial genomics2026

Nanopore sequencing enables highly accurate genotyping and identification of resistance determinants in key nosocomial pathogens.

Hugh Cottingham, Louise M Judd, Taylor Harshegyi-Hand, Jessica A Wisniewski, Luke V Blakeway, Tiffany Hong, Matthew H Parker, Anton Y Peleg, Kathryn E Holt, Jane Hawkey and 1 more

Abstract read
In one paragraph

Article in Microbial genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hugh CottinghamDepartment of Infectious Diseases, The Alfred and School of Translational Medicine, Monash University, Melbourne, Victoria 3004, Australia.
Louise M JuddDepartment of Infectious Diseases, The Alfred and School of Translational Medicine, Monash University, Melbourne, Victoria 3004, Australia.
Taylor Harshegyi-HandDepartment of Infectious Diseases, The Alfred and School of Translational Medicine, Monash University, Melbourne, Victoria 3004, Australia.
Jessica A WisniewskiDepartment of Infectious Diseases, The Alfred and School of Translational Medicine, Monash University, Melbourne, Victoria 3004, Australia.
Luke V BlakewayDepartment of Infectious Diseases, The Alfred and School of Translational Medicine, Monash University, Melbourne, Victoria 3004, Australia.
Tiffany HongDepartment of Infectious Diseases, The Alfred and School of Translational Medicine, Monash University, Melbourne, Victoria 3004, Australia.
Matthew H ParkerDepartment of Infectious Diseases, The Alfred and School of Translational Medicine, Monash University, Melbourne, Victoria 3004, Australia.
Anton Y PelegDepartment of Infectious Diseases, The Alfred and School of Translational Medicine, Monash University, Melbourne, Victoria 3004, Australia.
Kathryn E HoltDepartment of Infectious Diseases, The Alfred and School of Translational Medicine, Monash University, Melbourne, Victoria 3004, Australia.
Jane HawkeyDepartment of Infectious Diseases, The Alfred and School of Translational Medicine, Monash University, Melbourne, Victoria 3004, Australia.
Nenad MacesicDepartment of Infectious Diseases, The Alfred and School of Translational Medicine, Monash University, Melbourne, Victoria 3004, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whole-genome sequencing of bacterial pathogens can positively impact infectious disease management in clinical contexts, both in individual settings and by assisting infection prevention efforts. However, logistical issues have often prevented its translation into clinical settings. Oxford Nanopore Technologies (ONT) platforms are flexible and affordable and now offer accuracy comparable to other sequencing platforms, making them uniquely well-suited for clinical bacterial isolate sequencing. We sought to determine the best methods for implementing ONT sequencing into clinical settings by benchmarking multi-locus sequence typing (MLST), core genome multi-locus sequence typing (cgMLST), antimicrobial resistance (AMR) and core genome SNP (cgSNP) typing against the genomic automated gold standard. We sequenced 199

Indexed as

BacteriaCross InfectionDrug Resistance, BacterialEnterobacteriaceaeGenotyping TechniquesNanopore SequencingGenome, BacterialGenotypeHigh-Throughput Nucleotide SequencingHumansMultilocus Sequence TypingPolymorphism, Single NucleotideWhole Genome Sequencingantimicrobial resistancebenchmarkinggenomic surveillanceGram-negative bacterialong-read sequencingOxford Nanopore

Identifiers

PMID41891186
PMCPMC13058751

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.