Evidence map›Paper›PMID 41891138›Full record

ArticleJournal of biophotonics2026

Infrared Photobiomodulation Modulates PpIX Production After Topical Methyl Aminolevulinate in Normal Human Skin: An Exploratory Study.

Letícia Palombo Martinelli, Natasha Ferreira Mezzacappo, Ana Paula Silva, Priscila Menezes, Vanderlei Salvador Bagnato

Abstract read
In one paragraph

Article in Journal of biophotonics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Letícia Palombo MartinelliSão Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil.ORCID 0000-0002-6747-1777
Natasha Ferreira MezzacappoSão Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil.
Ana Paula SilvaEmipharma Indústria e Comércio de Produtos Fármacos Ltda, São Carlos, São Paulo, Brazil.
Priscila MenezesSão Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil.
Vanderlei Salvador BagnatoSão Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil.ORCID 0000-0003-4833-239X

Funding

Chancellor's Research Initiative (CPRIT) R220054EMBRAPII PIFS-2503.0086GURINational Council for Scientific and Technological Development 385534/2024-8National Council for Scientific and Technological Development 440237/2021-1São Paulo Research Foundation 2013/07276-1São Paulo Research Foundation 2014/50857-8the Coordination for the Improvement of Higher Education Personnel (CAPES)
6 · The paper itself

Abstract

Photodynamic therapy (PDT) for skin lesions requires optimized photosensitizer accumulation. Since protoporphyrin IX (PpIX) synthesis is linked to mitochondrial activity, photobiomodulation (PBM) may modulate this process. This exploratory study examined the effects of PBM at 780 or 808 nm on MAL-induced PpIX in normal human skin. Eleven volunteers received paired-arm treatments (5, 10, or 15 J/cm

Indexed as

Aminolevulinic AcidInfrared RaysPhotosensitizing AgentsProtoporphyrinsSkinAdministration, TopicalAdultFemaleHumansMaleYoung AdultAminolevulinic Acidmethyl 5-aminolevulinatePhotosensitizing Agentsprotoporphyrin IXProtoporphyrinsclinical trialmethyl AminolevulinatePhotobiomodulationphotodynamic therapyProtoporphyrin IX

Identifiers

PMID41891138
PMCPMC13022744

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.