Evidence map›Paper›PMID 41891104›Full record

ArticleToxicology reports2026

Neonicotinoid pesticides disrupt gingival epithelial barrier function.

Tsukasa Tamamori, Keita Tanigaki, Sasaki Naoko, Risako Matsumura, Shunsuke Yamaga, Akito Sakanaka, Hiromasa Tsujiguchi, Akinori Hara, Atsuo Amano, Michiya Matsusaki and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tsukasa TamamoriDepartment of Preventive Dentistry, Graduate School of Dentistry, The Osaka University, Suita-Osaka 565-0871, Japan.
Keita TanigakiDepartment of Preventive Dentistry, Graduate School of Dentistry, The Osaka University, Suita-Osaka 565-0871, Japan.
Sasaki NaokoJoint Research Laboratory (TOPPAN) for Advanced Cell Regulatory Chemistry, Graduate School of Engineering, The Osaka University, Suita‑Osaka 565‑0871, Japan.
Risako MatsumuraDepartment of Preventive Dentistry, Graduate School of Dentistry, The Osaka University, Suita-Osaka 565-0871, Japan.
Shunsuke YamagaDepartment of Preventive Dentistry, The Osaka University Dental Hospital, Suita-Osaka 565-0871, Japan.
Akito SakanakaDepartment of Preventive Dentistry, Graduate School of Dentistry, The Osaka University, Suita-Osaka 565-0871, Japan.
Hiromasa TsujiguchiDepartment of Hygiene and Public Health, Graduate School of Medical Sciences, The Kanazawa university, Kanazawa-Ishikawa 920-8640, Japan.
Akinori HaraDepartment of Hygiene and Public Health, Graduate School of Medical Sciences, The Kanazawa university, Kanazawa-Ishikawa 920-8640, Japan.
Atsuo AmanoDepartment of Preventive Dentistry, Graduate School of Dentistry, The Osaka University, Suita-Osaka 565-0871, Japan.
Michiya MatsusakiDepartment of Applied Chemistry, Graduate School of Engineering, The Osaka University, Suita‑Osaka 565‑0871, Japan.
Hiroyuki NakamuraDepartment of Hygiene and Public Health, Graduate School of Medical Sciences, The Kanazawa university, Kanazawa-Ishikawa 920-8640, Japan.
Hiroki TakeuchiDepartment of Preventive Dentistry, The Osaka University Dental Hospital, Suita-Osaka 565-0871, Japan.
Masae KuboniwaDepartment of Preventive Dentistry, Graduate School of Dentistry, The Osaka University, Suita-Osaka 565-0871, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonicotinoid pesticides are highly persistent in the environment, with detection in periodontal blood reported. Although an association with gingival inflammation has been shown, the mechanism related to periodontal disease remains unclear. Previous study found that coxsackievirus and adenovirus receptor (CXADR) is involved in gingival tissue epithelial barrier function, thus the effects of neonicotinoids on CXADR were examined. High performance liquid chromatography of salivary samples from 16 volunteers detected acetamiprid, clothianidin, imidacloprid, and thiamethoxam. Administration of neonicotinoids (Σneonicotinoids) resulted in loss of cell-surface CXADR, which was restored by bafilomycin A1, a lysosomal inhibitor. Using a three-dimensional tissue model of human gingival epithelial cells, Σneonicotinoids were found to increase permeability to lipopolysaccharide (LPS) and peptidoglycan (PGN), which was dependent on CXADR. It is thus suggested that neonicotinoids cause mislocalization of CXADR into lysosomes, leading to gingival barrier function disruption, which allows for bacterial virulence factors to penetrate subepithelial tissues.

Indexed as

CXADRGingival epithelial cellsNeonicotinoidPeriodontitisPesticidePorphyromonas gingivalis

Identifiers

PMID41891104
PMCPMC13015243

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.