ArticleClinical ophthalmology (Auckland, N.Z.)2026
Multimodal Imaging of Yellow-White Transformation in Chorioretinal Hemorrhages: Structural and Biochemical Insights.
Article in Clinical ophthalmology (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To investigate clinical and multimodal imaging characteristics of chorioretinal hemorrhages that undergo yellow-white transformation, focusing on optical coherence tomography (OCT) reflectivity and fundus autofluorescence (FAF). Patients and Methods: Sixty-five eyes with acute hemorrhage due to polypoidal choroidal vasculopathy (n=30), ruptured retinal arterial macroaneurysm (n=30), or retinal vein occlusion (n=5), which were followed monthly until resolution or transformation at Kyoto University Hospital between 2015 and 2016, were retrospectively reviewed. Lesion depth was classified on OCT as preretinal, subinternal limiting membrane, intraretinal, subretinal, or subretinal pigment epithelium. Reflectivity and FAF intensity were normalized against internal references and compared between red and yellow-white lesions. Results: Yellow-white transformation occurred most frequently in subretinal hemorrhages (18/47; 38.3%) and never within the neural retina. The mean time to transformation was 30-40 days. Compared with red lesions, yellow-white lesions showed significantly higher OCT reflectivity (1.15 ± 0.33 vs 0.71 ± 0.29) and higher FAF intensity (1.13 ± 0.46 vs -0.01 ± 0.24; both P < 0.001). Conclusion: Yellow-white transformation reflects structural and biochemical remodeling occurring outside the sensory retina, most often in the subretinal compartment. The consistent OCT and FAF signatures likely reflect accumulation of hemoglobin degradation products or phagocyte-derived material, and may assist in distinguishing hemorrhagic remodeling from other clinically white-appearing fundus lesions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.