Evidence map›Paper›PMID 41891082›Full record

ArticleInternational journal of transgender health2026

QT interval changes in transgender/gender diverse adolescents receiving gonadotropin-releasing hormone agonist and gender-affirming hormonal treatment.

Hussein Zaitoon, Livia Kapusta, Galit Israeli, Anat Segev-Becker, Gil Beer, Alexander Lowenthal, Gili Yaeger Yarom, Asaf Oren, Liat Perl

Abstract read
In one paragraph

Article in International journal of transgender health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hussein ZaitoonThe Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv, Israel.ORCID https://orcid.org/0000-0002-4979-3799
Livia KapustaPediatric Cardiology Institute, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.ORCID https://orcid.org/0000-0001-9794-8161
Galit IsraeliThe Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv, Israel.
Anat Segev-BeckerThe Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv, Israel.ORCID https://orcid.org/0000-0002-6474-3618
Gil BeerPediatric Cardiology Institute, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Alexander LowenthalPediatric Cardiology Institute, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.ORCID https://orcid.org/0000-0001-7420-3044
Gili Yaeger YaromPediatric Cardiology Institute, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Asaf OrenThe Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv, Israel.ORCID https://orcid.org/0000-0002-2790-8866
Liat PerlThe Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv, Israel.ORCID https://orcid.org/0000-0002-8207-1130

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: To evaluate QTc interval changes in transgender/gender-diverse (TGD) adolescents undergoing GnRHa and GAHT. Methods: This prospective study included 39 TGD adolescents (20 females), mean age 15.6 ± 1.4 years, Tanner stage 4-5. QTc intervals were measured before and after GnRHa treatment and following GAHT initiation. Results: The mean QTc increased significantly from 382.4 ± 16.2 ms at baseline to 402.9 ± 20.1 ms after GnRHa treatment ( Discussion and conclusion: QTc prolongation was observed in TGD female adolescents after the initiation of GnRHa, while TGD males showed a decrease in QTc following testosterone administration. Further studies on the clinical implications of QT interval changes in this population are warranted.

Indexed as

Cardiac repolarizationgender-affirming hormonal treatmentlong QTQT intervalshort QTtransgender/gender diverse youth

Identifiers

PMID41891082
PMCPMC13015028

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.