Evidence map›Paper›PMID 41891006›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Culture-enriched metagenomic sequencing reveals within-patient diversity and transmission of vancomycin-resistant

Emma G Mills, Kirsten M Evans, Ava J Dorazio, Kevin M Squires, Alexander J Sundermann, Madison E Stellfox, Matthew J Culyba, Ryan K Shields, Daria Van Tyne

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Emma G MillsDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kirsten M EvansDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0009-0002-5103-3438
Ava J DorazioDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0009-0007-8148-8835
Kevin M SquiresDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0009-0007-7818-905X
Alexander J SundermannMicrobial Genomic Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-2439-6287
Madison E StellfoxDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-1478-5190
Matthew J CulybaDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-8327-4135
Ryan K ShieldsDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-9794-5665
Daria Van TyneDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-7284-0103

Funding

Enhanced Detection System for Healthcare-Associated Transmission of InfectionR01AI127472 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRISON, LEE H · 2016 to 2025
$7.6M
Adaptation of vancomycin-resistant enterococci during bloodstream infectionR01AI165519 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VAN TYNE, DARIA N · 2022 to 2025
$3.0M
NIAID NIH HHS R01 AI127472NIAID NIH HHS R01 AI165519
6 · The paper itself

Abstract

Colonization of the gastrointestinal (GI) tract by vancomycin-resistant

Indexed as

culture-enriched metagenomicsgenomic epidemiologypopulation genomicsVancomycin-resistant Enterococcus faeciumVREwithin-patient diversity

Identifiers

PMID41891006
PMCPMC13015639

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.