Evidence map›Paper›PMID 41891001›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Prenatal exposure to SARS-CoV-2, early relational health, and child socio-emotional functioning in the first 6 months.

Andréane Lavallée, Jennifer M Warmingham, Jill B Owen, Ruiyang L Xu, Imaal Ahmed, Ginger D Atwood, Margaret H Kyle, Maha Hussain, Vitoria Chaves, Elena Arduin and 41 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

51 authors.

Andréane LavalléeCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.ORCID 0000-0001-5702-3084
Jennifer M WarminghamMt. Hope Family Center University of Rochester, Rochester, New York.ORCID 0000-0003-4215-5126
Jill B OwenCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Ruiyang L XuCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Imaal AhmedCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Ginger D AtwoodCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Margaret H KyleCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Maha HussainCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Vitoria ChavesCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Elena ArduinCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Marissa R LanoffCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Sabrina P HymanCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Lerzan Z CoskunDepartment of Population Health, NYU Grossman School of Medicine, New York, New York.
Nicole ShearmanCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Jenna E RussoCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Sharon EttingerDepartment of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.
Esther A GreemanCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Danielle E SerotaCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Mary L BenceCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Violet HottCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Yunzhe HuDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.
Georgia KurmanCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Mayerly LaraCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Helen Tzul LopezCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Isabelle MolliconeCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Rupa RaviCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Cynthia RodriguezCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Grace C SmotrichDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.
Aoife LawlessCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Perla Ontiveros-ÁngelCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Austen CurtinCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Judy AustinHeilbrunn Department of Population and Family Health, Mailman School of Public Health, Columbia University Irving Medical Center, New York, New York.
Morgan R FiresteinDepartment of Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.
Lauren C ShuffreyDepartment of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, New York, New York.
Cristina R FernándezCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Ashley N BattarbeeDepartment of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama.
Ann BrunoDepartment of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah.
Fatimah S DawoodCOVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
Panagiotis ManiatisCOVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
Tyler C MorrillAbt Global, Rockville, Maryland.
Gabriella Newes-AdeyiAbt Global, Rockville, Maryland.
Lawrence ReichleAbt Global, Rockville, Maryland.
Vera SemenovaCOVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
Alan T TitaDepartment of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama.
Michael VarnerDepartment of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah.
Kristina WielgoszCOVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.ORCID 0000-0001-6006-5963
Rachel MarshDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.
Paul CurtinCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.
Melissa S StockwellHeilbrunn Department of Population and Family Health, Mailman School of Public Health, Columbia University Irving Medical Center, New York, New York.ORCID 0000-0002-2113-7247
Catherine MonkDepartment of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.
Dani DumitriuCenter for Early Relational Health, Columbia University Irving Medical Center, New York, New York.

Funding

Structural and Social Determinants of Maternal Mental Health, Morbidity, and Inequities in COMBOR01MH126531 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DUMITRIU, DANI, MARSH, RACHEL · 2021 to 2025
$4.7M
Emotional and biobehavioral mechanisms of parent-infant emotional synchronyK99HD115784 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAVALLEE, ANDREANE · 2024 to 2025
$263k
NICHD NIH HHS K99 HD115784NIMH NIH HHS R01 MH126531
6 · The paper itself

Abstract

Importance: Parent/caregiver-infant early relational health (ERH) is known to play a critical role in the promotion of socio-emotional functioning and wellbeing across the life course. The negative impact of the COVID-19 pandemic on maternal mental health and secondarily on ERH and child socio-emotional functioning is clear. However, the direct impact of maternal viral exposure during pregnancy on ERH has not been investigated. Objective: The goal of this study was to determine the impact of prenatal SARS-CoV-2 exposure on ERH and infant socio-emotional functioning in the first 6 months of life. Design: Mothers with and without SARS-CoV-2 exposure during pregnancy who gave birth from 02/2020 to 09/2021 were enrolled from 05/2020 to 09/2021 in one of two parallel prospective studies (the COVID-19 Mother Baby Outcomes [COMBO] Initiative or the Respiratory Syndrome Coronavirus 2 in Pregnancy and Infancy [ESPI] COMBO sub-study). Mothers reported on their health and the socio-emotional functioning of their infant via online surveys (REDCap) at enrollment, 1, 2, 4, and 6 months. At 4 to 6 months, dyads were invited to participate in a video-based, remote assessment of ERH. Participants: 884 mother-infant dyads from three U.S. States (Alabama, New York, and Utah). Exposure: Prenatal SARS-CoV-2. Main Outcomes and Measures: Maternal-reported ERH (parental stress, parenting confidence and bonding) and observer-based ERH (video-coded quality of maternal caregiving behaviors and mother-infant emotional connection). Infant socio-emotional development assessed using the 6-month Ages and Stages Questionnaire: Socio-Emotional 2 Results: 316 (36%) mothers had a positive prenatal SARS-CoV-2 exposure. Prenatal SARS-CoV-2 exposure was associated with an adjusted estimate of ~5% reduction (incidence rate ratio=0.95, 95% confidence interval [0.90, 1.00], p=0.03) in observed maternal caregiving quality, after accounting for postnatal maternal mental health and sociodemographic factors. We found no evidence of effect on other ERH constructs or infant socio-emotional functioning. Conclusions and Relevance: In this large prospective cohort study, prenatal SARS-CoV-2 was associated with a small decrement in caregiving quality, but not other ERH constructs or infant socio-emotional functioning. These findings should be interpreted as hypothesis generating and will require replication in independent studies.

Identifiers

PMID41891001
PMCPMC13015689

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