ArticleiScience2026
Induction of adipocyte thermogenic program by Rho-associated coiled-coil containing kinase 2.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Beige adipocytes develop within subcutaneous white adipose tissue (sWAT) and contribute to thermogenesis, vital for survival during cold exposure. Rho-associated coiled-coil containing kinase (ROCK) inhibitors have been found to promote white adipocyte differentiation. However, the adipocyte-specific role of ROCK2, the predominant ROCK isoform in adipocytes, in cold-induced thermogenesis is uncertain. Here, we show that ROCK2 in adipocytes is necessary for cold-induced adaptive beiging and thermogenesis. Cold exposure triggered a rapid ROCK activation in both sWAT and interscapular brown adipose tissue (iBAT) from wild-type mice. Mice lacking ROCK2 expression in adipocytes exhibited less cold-induced beige adipocyte development in sWAT and reduced thermogenesis in iBAT. In sWAT, cold-induced upregulation and nuclear translocation of forkhead box protein O1 (FOXO1) were critical for the ROCK2-mediated expression of thermogenic gene uncoupling protein 1 (
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