Evidence map›Paper›PMID 41890953›Full record

ArticleMaterials today. Bio2026

Mesoporous bioactive glass hybrid nanoparticles accelerate tendon-bone healing via synergistic angiogenesis and immunomodulation.

Yongjun Chen, Haiyan Yao, Chen Li, Yun Zhou, Junlin Ren, Runhui Liu, Junchao Wei, Liang Hao

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Yongjun ChenDepartment of Orthopedics, The Second Affiliated Hospital, Jiangxi, Medical College, Nanchang University, Nanchang, 330088, China.
Haiyan YaoSchool of Chemistry and Chemical Engineering, Nanchang University, Nanchang, 330031, China.
Chen LiDepartment of Orthopedics, The Second Affiliated Hospital, Jiangxi, Medical College, Nanchang University, Nanchang, 330088, China.
Yun ZhouDepartment of Orthopedics, The Second Affiliated Hospital, Jiangxi, Medical College, Nanchang University, Nanchang, 330088, China.
Junlin RenDepartment of Orthopedics, The Second Affiliated Hospital, Jiangxi, Medical College, Nanchang University, Nanchang, 330088, China.
Runhui LiuDepartment of Orthopedics, The Second Affiliated Hospital, Jiangxi, Medical College, Nanchang University, Nanchang, 330088, China.
Junchao WeiSchool of Chemistry and Chemical Engineering, Nanchang University, Nanchang, 330031, China.
Liang HaoDepartment of Orthopedics, The Second Affiliated Hospital, Jiangxi, Medical College, Nanchang University, Nanchang, 330088, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A critical clinical challenge for Rotator cuff tear (RCT) treatment is to enhance tendon-bone healing, which is greatly affected by insufficient vascularization, chronic inflammation, and oxidative stress. In this work, a novel nanoparticle, MBG@SeHA/Sim, was designed to synergistically promote angiogenesis, modulate the immune response and promote bone regeneration, thereby accelerating tendon-bone healing. The comprehensive in vitro assays demonstrated that MBG@SeHA/Sim showed superior capabilities in promoting vascularization, mitigating inflammation, and stimulating bone regeneration. Besides, mechanistic studies suggested that the anti-inflammatory action of MBG@SeHA/Sim may involve the MAPK, NF-κB, and PI3K/Akt signaling pathways. In vivo, animal experiments demonstrated that MBG@SeHA/Sim can effectively promote tendon-bone healing. Overall, these findings demonstrated that MBG@SeHA/Sim effectively promotes tendon-bone healing through multiple functions and presents a viable approach to address the clinical challenge of suboptimal healing after rotator cuff repair surgery.

Indexed as

AngiogenesisAnti-inflammationMesoporous bioactive glassTendon-bone healing

Identifiers

PMID41890953
PMCPMC13014926

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.