ArticleFrontiers in cell and developmental biology2026
A conserved bioelectrical signature defines subventricular zone-derived human fetal neural stem cells and tracks their differentiation state.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Absolute voltage mapping using dynamic photocycle control.bioRxiv : the preprint server for biology · 2026Article
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10 authors.
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Abstract
Introduction: Human fetal neural stem cells (hfNSCs) from the subventricular zone (SVZ) are employed in clinical trials for neurodegenerative diseases, yet their bioelectrical properties remain largely unexplored. Molecular markers alone do not reliably correlate with functional state, highlighting the need for complementary functional descriptors. Methods: We performed whole-cell patch-clamp recordings on hfNSCs from three independent SVZ donors (15-16 weeks of gestation) to characterize resting membrane potential (Vm) and voltage-gated currents, assessing inter-donor reproducibility and differentiation dynamics over 30 days Results: hfNSCs exhibited a highly reproducible bioelectrical signature across all donors, characterized by a depolarized resting membrane potential (∼-30 mV), a non-excitable profile, and a stereotyped composition of outward K+ currents. The two current components were resolved using combined biophysical and pharmacological approaches, while Western blot analysis confirmed the expression of Kv4.2 and Kv1.1 channel subtypes functionally consistent with I Conclusion: SVZ-derived hfNSCs possess a reproducible bioelectrical signature within the 15-16-week gestational window across independent donors, supporting electrophysiological profiling as a quantitative functional benchmark for identity and standardization. During
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