Evidence map›Paper›PMID 41890841›Full record

ArticleResearch square2026

Kidney Dysfunction In Young People Living With HIV On Dolutegravir-Based Regimens In Kampala, Uganda.

Esther M Nasuuna, Risa Hoffman, Robert Kalyesubula, Chido Dziva Chikwari, Helen A Weiss

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PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Esther M NasuunaNon-communicable Diseases Program, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit.
Risa HoffmanDavid Geffen School of Medicine, University of California Los Angeles.
Robert KalyesubulaNon-communicable Diseases Program, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit.
Chido Dziva ChikwariBiomedical Research and Training Institute.
Helen A WeissMRC International Statistics and Epidemiology Group, London School of Hygiene & Tropical Medicine.

Funding

HIV Co-infections in Uganda: TB, Cryptococcus, and Viral Hepatitis.D43TW009771 · FIC · JOHNS HOPKINS UNIVERSITY · PI CASTELNUOVO, BARBARA, KAMBUGU, ANDREW DDUNGU · 2014 to 2023
$3.3M
FIC NIH HHS D43 TW009771
6 · The paper itself

Abstract

We assessed the association between dolutegravir (DTG)-based antiretroviral therapy and kidney abnormalities among young people living with HIV aged 10-24 years in Kampala, Uganda. In this cross-sectional study, albumin-creatinine ratio (ACR), proteinuria, and estimated glomerular filtration rate (eGFR) were measured. Among 483 participants, 78% received tenofovir (TDF)/DTG. Mean serum creatinine was higher and creatinine-based eGFR lower among those on TDF/DTG, while cystatin C and cystatin C-based eGFR were similar. The prevalence of elevated ACR, proteinuria, and eGFR <90 ml/min/1.73m

Indexed as

dolutegravirKidney functionSub Saharan Africayoung people living with HIV

Identifiers

PMID41890841
PMCPMC13015607

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.