Evidence map›Paper›PMID 41890832›Full record

ArticleResearch square2026

Operant behavior is reliably impaired in a mouse model of Angelman syndrome.

Caleigh D Guoynes, Devante D Kerr, Zahraa S Hotait, Joseph K Tanas, Michael S Sidorov

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Caleigh D GuoynesCenter for Neuroscience Research, Children's National Hospital, Washington, DC, USA.
Devante D KerrCenter for Neuroscience Research, Children's National Hospital, Washington, DC, USA.
Zahraa S HotaitCenter for Neuroscience Research, Children's National Hospital, Washington, DC, USA.
Joseph K TanasCenter for Neuroscience Research, Children's National Hospital, Washington, DC, USA.
Michael S SidorovCenter for Neuroscience Research, Children's National Hospital, Washington, DC, USA.

Funding

Neurobehavioral Evaluation CoreP50HD105328 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI WILLIAM Davis GAILLARD · 2021 to 2026
$9.3M
District of Columbia T32 on Neurodevelopmental Disabilities Research (DC NDD T32)T32NS115656 · NINDS · CHILDREN'S RESEARCH INSTITUTE · PI BERL, MADISON MEHALANI, SIDOROV, MICHAEL S · 2021 to 2025
$1.8M
Mechanisms of Visual Encoding and Plasticity in Anterior Cingulate CortexR00EY028964 · NEI · CHILDREN'S RESEARCH INSTITUTE · PI SIDOROV, MICHAEL S · 2020 to 2022
$831k
NEI NIH HHS R00 EY028964NICHD NIH HHS P50 HD105328NINDS NIH HHS T32 NS115656
6 · The paper itself

Abstract

Angelman syndrome (AS) is a neurodevelopmental disorder characterized by cognitive impairment, absent speech, seizures, motor and sleep impairments, and caused by loss of function of the maternal copy of the

Indexed as

Angelman syndromemouse behaviorneurodevelopmental disordersUbe3a

Identifiers

PMID41890832
PMCPMC13015589

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.