Evidence map›Paper›PMID 41890827›Full record

ArticleResearch square2026

Mast cell specific receptor Mrgprb2/X2 regulates bladder immunity during urinary tract infections.

Waris Muhammad Khuwaja, Colin Guth, Sudeshna Rakshit, Linghui Nie, Zahra Janjua, Nicole De Nisco, Priyanka Pundir, Dustin Green, Xintong Dong

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Waris Muhammad KhuwajaDepartment of Biological Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.ORCID https://orcid.org/0000-0003-3397-5747
Colin GuthDepartment of Molecular and Cellular Biology, College of Biological Science, University of Guelph, Guelph, ON N1G 2W1, Canada.
Sudeshna RakshitDepartment of Neurobiology, University of Texas Medical Branch, Galveston, TX, USA.
Linghui NieDepartment of Neurobiology, University of Texas Medical Branch, Galveston, TX, USA.
Zahra JanjuaDepartment of Biological Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.
Nicole De NiscoDepartment of Biological Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.ORCID https://orcid.org/0000-0002-7670-5301
Priyanka PundirDepartment of Molecular and Cellular Biology, College of Biological Science, University of Guelph, Guelph, ON N1G 2W1, Canada.
Dustin GreenDepartment of Neurobiology, University of Texas Medical Branch, Galveston, TX, USA.ORCID https://orcid.org/0000-0003-2046-1915
Xintong DongDepartment of Biological Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.ORCID https://orcid.org/0000-0002-6887-8712

Funding

Genetic dissection of defensin signaling in urinary tract infectionsR01DK140039 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI Xintong Dong · 2024 to 2026
$1.8M
The role of neuro-immune interactions in PACAP induced migraineR01NS131507 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Dustin Pepper Green · 2024 to 2026
$1.4M
NIDDK NIH HHS R01 DK140039NINDS NIH HHS R01 NS131507
6 · The paper itself

Abstract

Urinary tract infections (UTIs) are the most common bacterial infections in women. During UTI, the host mounts a rapid immune response to clear the invading pathogen. Mast cells are tissue resident immune cells found in the bladder lamina propria and can serve as first responders to bacterial infections. We investigated the role of the mouse mast cell receptor Mrgprb2 and its human homologue MRGPRX2 in UTI. During acute UTI, Mrgprb2 is activated by the antimicrobial peptide cathelicidin and mediates mast cell degranulation. Using

Identifiers

PMID41890827
PMCPMC13015594

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.