ArticleFrontiers in neuroscience2026
Comparative analysis of maze complexity: implications for adult hippocampal neurogenesis.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Humanised Environmental Enrichment: Spatial Effects of Cities and Buildings on Adult Hippocampal Neurogenesis in Humans.International journal of molecular sciences · 2026Review
- Built Environment-Modulated Epigenetics: The Epigenetic Consequences of Architecturally Mediated Allostatic Overload in the Built Environment.International journal of environmental research and public health · 2026Review
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Authors and funding
1 author.
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Abstract
Adult hippocampal neurogenesis persists throughout the lifespan in mammals and can be enhanced by environmental enrichment, including spatial complexity. Whilst maze-based enrichment has been suggested to increase neurogenesis in rodents, the relative complexity of different maze architectures has not been quantified, limiting translational research to human environments. This study used the Architectural Spatial Complexity Index (A-SCI), a novel tool, to compare spatial complexity across 16 rodent maze configurations, including mazes suggested to increase neurogenesis. Results confirm that the A-SCI significantly differentiates environmental enrichment from standard housing, whilst post-hoc analysis suggests no significant difference between maze-based and object-based enrichment, consistent with previous research reporting almost similar effects on cortical thickness. Comparative analysis revealed substantial variation in complexity across rodent maze architectures. Future research can use the A-SCI tool to validate the effect of maze complexity on adult hippocampal neurogenesis, while the Hampton Court maze may be a promising translational paradigm from rodents to humans.
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