ReviewJournal of pain research2026
Abnormal Regional Brain Functional Activity and Brain Network Connectivity in Primary Trigeminal Neuralgia Patients: An Activation Likelihood Estimation Meta-Analysis Based on Resting-State fMRI.
Review in Journal of pain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Resting-state local brain functional synchronization after a single trigger-zone stimulation: with versus without evoked pain in classical trigeminal neuralgia patients.The journal of headache and pain · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study integrates resting-state functional magnetic resonance imaging (rs-fMRI) studies to systematically identify core regions of altered regional brain activity and abnormal functional connectivity within cerebral networks in patients with primary trigeminal neuralgia (PTN). Methods: We systematically searched PubMed, Web of Science, and EMBASE for rs-fMRI studies (between January 2010 and June 2025) comparing PTN patients with healthy controls (HCs). Through a standardized data extraction protocol, coordinates of divergent brain functional metrics and network connectivity parameters were collected. Ultimately, we included 16 studies, of which 14 were related to functional specific indices (375 patients) and 5 to functional connectivity (204 patients). Separate modality-specific Activation Likelihood Estimation (ALE) meta-analyses were conducted for studies employing Amplitude of Low-Frequency Fluctuation (ALFF/fALFF), Regional Homogeneity (ReHo), and Degree Centrality (DC), to reflect their unique neurophysiological meanings. Results: ALE analysis revealed index-specific alteration patterns with limited spatial overlap. The ALFF/fALFF analysis identified consistent hypoactivity in the left medial prefrontal cortex. In contrast, ReHo and DC analyses converged to show hyperactivity in the posterior cerebellar lobe and temporal pole. Notably, Seed-based functional connectivity analyses yielded no convergent findings, and limbic system activation was highly heterogeneous. Conclusion: Our meta-analysis demonstrates that PTN involves complex, multidimensional brain remodeling, not a dysfunction of a single "pain center." The distinct spatial patterns identified by different rs-fMRI metrics underscore their complementary value in uncovering PTN pathophysiology. These findings advance the understanding of PTN's central mechanisms, support the development of targeted interventions, and highlight the need to differentiate neurophysiological metrics and clinical subtypes in future research.
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Registered trials
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