ArticleJAC-antimicrobial resistance2026
In a bind: a quality improvement project for reducing fluoroquinolones drug-drug interactions with multivalent cations.
Article in JAC-antimicrobial resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
5 authors.
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Abstract
Introduction: Fluoroquinolone (FQ) co-administration with multivalent cations can decrease the bioavailability of the FQ significantly. This interaction is an independent risk factor for FQ resistance, which is a concern as more clinical trials and guidelines support routine use of oral antimicrobials. Methods: We examined the incidence of FQ drug-drug interactions (DDIs) in a quality improvement study after implementation of a bundle of interventions including nursing education, updated medication administration record (MAR) comments and new administration times. Results: In the subgroup of patients ( Conclusion: The bundle of interventions decreased but did not eliminate the interaction. With the interaction as an independent risk factor for resistance and increasing use of oral antibiotics, stewardship programmes should consider implementing similar interventions.
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Registered trials
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