Exploring the relationship between serum magnesium levels, genetic variants and chronic kidney disease: a prospective study.

Sisi Xie, Idris Guessous, Dela Golshayan, Aurélien Thomas, Julien Vaucher, Pedro Marques-Vidal

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In one paragraph

Article in Clinical kidney journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Sisi XieDepartment of Medicine, Division of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Idris GuessousPrimary care medicine service, Department of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.

Dela GolshayanDepartment of Medicine, Transplantation Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Aurélien ThomasFaculty Unit of Toxicology, CURML, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0001-6790-2285

Julien VaucherDepartment of Medicine, Division of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Pedro Marques-VidalDepartment of Medicine, Division of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-4548-8500

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Recent evidence suggests that magnesium deficiency may play a role in the development and progression of chronic kidney disease (CKD). We assessed the association between genetic variations, serum magnesium levels and CKD risk in the general population. Methods: In this population-based prospective study ( Results: Multivariable Cox regression analyses identified that hypomagnesemia was significantly associated with an increased risk of CKD, with a hazard ratio of 1.73 (95% confidence interval 1.14-2.61, Conclusions: Hypomagnesemia was significantly associated with an increased risk of long-term CKD. Genetic analysis suggests that serum magnesium levels may play an indirect role in CKD risk, but no clear causal relationship was found.

Indexed as

chronic kidney diseasehypomagnesemiamediation analysisMendelian randomizationsingle-nucleotide polymorphism

Identifiers

PMID41890552

DOI10.1093/ckj/sfaf254

PMCPMC13014121

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