Evidence map›Paper›PMID 41890533›Full record

ArticleAdvances in radiation oncology2026

Gamma Knife Stereotactic Radiosurgery With a Reduced Peripheral Dose: Outcomes in Uveal Melanoma Patients.

Lily Kollitz, Shubhendu Mishra, Ashley Gao, Guneet Sodhi, Peter H Tang, Yoichi Watanabe, Andrew S Venteicher, Dara Koozekanani, Clara Ferreira, Evidio Domingo-Musibay and 4 more

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Article in Advances in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lily KollitzUniversity of Minnesota, Minneapolis, Minnesota.
Shubhendu MishraDepartment of Radiation Oncology, University of Minnesota, Minneapolis, Minnesota.
Ashley GaoUniversity of Minnesota, Minneapolis, Minnesota.
Guneet SodhiRetina Consultants of Minnesota, Minneapolis, Minnesota.
Peter H TangStorm Eye Institute, Medical University of South Carolina, Charleston, South Carolina.
Yoichi WatanabeDepartment of Radiation Oncology, University of Minnesota, Minneapolis, Minnesota.
Andrew S VenteicherDepartment of Neurosurgery, University of Minnesota, Minneapolis, Minnesota.
Dara KoozekananiDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota.
Clara FerreiraDepartment of Radiation Oncology, University of Minnesota, Minneapolis, Minnesota.
Evidio Domingo-MusibayAllina Health, Minneapolis, Minnesota.
Jianling YuanDepartment of Radiation Oncology, University of Minnesota, Minneapolis, Minnesota.
Margaret A ReynoldsDepartment of Radiation Oncology, University of Minnesota, Minneapolis, Minnesota.
Lindsey SloanDepartment of Radiation Oncology, University of Minnesota, Minneapolis, Minnesota.
Kathryn E DusenberyDepartment of Radiation Oncology, University of Minnesota, Minneapolis, Minnesota.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Gamma Knife stereotactic radiosurgery (GK SRS) is an established alternative option for treating uveal melanoma in appropriate candidates. Despite proven efficacy, the optimal GK SRS dose remains uncertain. This study evaluated the safety and efficacy of a reduced-dose protocol. Methods and Materials: In this retrospective study, 24 adult patients with medium- or large-sized uveal melanoma unsuitable for plaque brachytherapy underwent GK SRS, with a median peripheral dose of 24 Gy. Local failure was defined according to the Collaborative Ocular Melanoma Study criteria. Kaplan-Meier methods were used to estimate local tumor control and vision outcomes. Results: In this cohort, 50% of patients had medium-sized tumors, and 50% had large-sized tumors. Local tumor control was 100% at 1 year and 95% at 2 years. There was no statistically significant difference in local control between medium and large tumors ( Conclusion: With favorable visual preservation, the 24 Gy dose yielded local tumor control comparable to that of previously published higher-dose protocols. Further investigations are warranted to define the dose that best balances tumor control and vision preservation in uveal melanoma.

Identifiers

PMID41890533
PMCPMC13014635

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