Evidence map›Paper›PMID 41890524›Full record

ArticleAnnals of surgery open : perspectives of surgical history, education, and clinical approaches2026

Value of Intraoperative Pancreatoscopy in Patients Undergoing Resection for Main-Duct Intraductal Papillary Mucinous Neoplasm: Thirty-Day Follow-Up of a Prospective International Study.

Urban Arnelo, Roberto Valente, Marc G Besselink, Christian Max Schmidt, Stuart Sherman, Guduru Venkat Rao, Richard A Burkhart, Yi Miao, Sohei Satoi, Rogier P Voermans and 9 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgery open : perspectives of surgical history, education, and clinical approaches, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03729453 (Intra-operative Pancreatoscopy in Patients With Intraductal Papillary Mucinous Neoplasm), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03729453 active not recruitingnot on this map

Intra-operative Pancreatoscopy in Patients With Intraductal Papillary Mucinous Neoplasm (IPMN)

TypeobservationalSponsorBoston Scientific CorporationRan2019 to 2027Enrolled100ConditionsIntraductal Papillary Mucinous NeoplasmArmsSpyGlass
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Urban ArneloFrom the Department of Diagnostics and Intervention, Surgery, Umeå University, Umeå, Sweden.
Roberto ValenteFrom the Department of Diagnostics and Intervention, Surgery, Umeå University, Umeå, Sweden.
Marc G BesselinkDepartment of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Christian Max SchmidtDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN.
Stuart ShermanDivision of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN.
Guduru Venkat RaoAsian Institute of Gastroenterology, Hyderabad, India.
Richard A BurkhartDivision of Hepatobiliary and Pancreatic Surgery, Johns Hopkins Hospital, Baltimore, MD.
Yi MiaoDepartment of General Surgery, Pancreas Center, The BenQ Medical Center Affiliated of Nanjing Medical University, Nanjing, China.
Sohei SatoiDepartment of Surgery, Kansai Medical University, Hirakata City, Osaka, Japan.
Rogier P VoermansCancer Center Amsterdam, VU University, Amsterdam, the Netherlands.
Shreeyash ModakAsian Institute of Gastroenterology, Hyderabad, India.
Steven EdmundowiczDivision of Surgical Oncology, Department of Surgery, University of Colorado, Anschutz Medical Campus, Denver, CO.
Olivier R BuschDepartment of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Kelly J LafaroDivision of Hepatobiliary and Pancreatic Surgery, Johns Hopkins Hospital, Baltimore, MD.
Jishu WeiDepartment of General Surgery, Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Joyce A PeetermansBoston Scientific Corporation, Marlborough, MA.
Matthew J RousseauBoston Scientific Corporation, Marlborough, MA.
Marco Del ChiaroDivision of Surgical Oncology, Department of Surgery, University of Colorado, Anschutz Medical Campus, Denver, CO.
Intraoperative Pancreatoscopy Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To report 30-day results from an ongoing 5-year study of intraoperative pancreatoscopy (IOP) in patients undergoing pancreatic surgery for main pancreatic duct (MPD) intraductal papillary mucinous neoplasm (IPMN). Background: IOP may detect skip lesions and objectify disease extent during surgery for IPMN with MPD involvement, but prospective multicenter data are lacking. Methods: Prospective international study including patients with IPMN and MPD diameter >5 mm on preoperative imaging, scheduled for surgery at 8 centers in 6 countries. Primary endpoint was the rate of detection by IOP of discontinuous (skip) lesions along the MPD. Secondary endpoints included IOP technical success, influence of IOP findings on surgical plan, and related serious adverse events (SAEs). Results: Among 100 patients undergoing IOP, skip lesions were documented in 13 (13.0%). IOP was technically successful in 91 (91.0%). In 41 patients (41.0%), IOP findings were reported by the surgeon to be impactful by confirming the absence of lesions in a dilated MPD and hence sparing parenchyma in 26 (26%), extending the initial resection in 12 (12%), or changing the type of partial pancreatectomy in 3 (3%). There were no IOP-related SAEs. Surgery-related SAEs were reported in 27 (27%) patients. Conclusions: IOP identified skip lesions in 13% of patients undergoing surgery for IPMN with MPD involvement. IOP influenced the surgical plan in 41% of patients. There were no IOP-related SAEs. Longer follow-up is ongoing. ClinicalTrials.gov number NCT03729453.

Indexed as

high-grade dysplasiaIPMNpancreatic cancerpancreatic surgerypancreatoscopy

Identifiers

PMID41890524
PMCPMC13016178

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