Evidence map›Paper›PMID 41890511›Full record

ArticleRSC medicinal chemistry2026

Exploration of a benzothiophene scaffold for use as adjuvants with β-lactam antibiotics against methicillin-resistant

Monica A Stefaniak, Vijay S Gondil, Emily P Gillis, Ansley M Nemeth, Allen G Oliver, Roberta J Melander, Paul M Dunman, Christian Melander

Abstract read
In one paragraph

Article in RSC medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Monica A StefaniakDepartment of Chemistry and Biochemistry, University of Notre Dame Notre Dame IN 46556 USA cmelande@nd.edu.
Vijay S GondilDepartment of Microbiology and Immunology, University of Rochester Medical Center Rochester New York 14642 USA paul_dunman@urmc.rochester.edu.
Emily P GillisDepartment of Chemistry and Biochemistry, University of Notre Dame Notre Dame IN 46556 USA cmelande@nd.edu.
Ansley M NemethDepartment of Chemistry and Biochemistry, University of Notre Dame Notre Dame IN 46556 USA cmelande@nd.edu.
Allen G OliverDepartment of Chemistry and Biochemistry, University of Notre Dame Notre Dame IN 46556 USA cmelande@nd.edu.ORCID https://orcid.org/0000-0002-0511-1127
Roberta J MelanderDepartment of Chemistry and Biochemistry, University of Notre Dame Notre Dame IN 46556 USA cmelande@nd.edu.
Paul M DunmanDepartment of Microbiology and Immunology, University of Rochester Medical Center Rochester New York 14642 USA paul_dunman@urmc.rochester.edu.
Christian MelanderDepartment of Chemistry and Biochemistry, University of Notre Dame Notre Dame IN 46556 USA cmelande@nd.edu.ORCID https://orcid.org/0000-0001-8271-4696

Funding

Project 2: Defining the Protective vs. Susceptible Immune Proteome of S. aureus OsteomyelitisP50AR072000 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2017 to 2026
$13.6M
Repurposing Gram-positive Antibiotics for Gram-Negative Bacteria using Antibiotic AdjuvantsR01AI167284 · NIAID · UNIVERSITY OF NOTRE DAME · PI MELANDER, CHRISTIAN COREY · 2022 to 2025
$3.7M
NIAID NIH HHS R01 AI167284NIAMS NIH HHS P50 AR072000
6 · The paper itself

Abstract

Rising antibiotic resistance coupled with diminishing investment in antibiotic development has led to limited treatment options for multi drug-resistant bacterial infections. Penicillin binding protein 2a (PBP2a) is a key determinant of resistance to many β-lactam antibiotics in methicillin-resistant

Identifiers

PMID41890511
PMCPMC13015963

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.