High-Throughput Automated Construction and Validation of Dicentric Chromosome and Micronucleus Biodosimetry Calibration Curves for Radiation Emergency Response.

Mengyun Wu, Haojun Li, Huadong Zhang, Wei Li, Yeqing Gu

Abstract read

In one paragraph

Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mengyun WuRadiology Laboratory, Department of Occupational Health and Radiological Health, Chongqing Center for Disease Control and Prevention, Chongqing, China.

Haojun LiTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin, China.

Huadong ZhangRadiology Laboratory, Department of Occupational Health and Radiological Health, Chongqing Center for Disease Control and Prevention, Chongqing, China.

Wei LiRadiology Laboratory, Department of Occupational Health and Radiological Health, Chongqing Center for Disease Control and Prevention, Chongqing, China.

Yeqing GuTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin, China.ORCID https://orcid.org/0000-0002-2420-1224

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Develop a high-throughput, fully automated workflow for dicentric chromosome and micronucleus assays to enable rapid, accurate radiation dose estimation in radiological or nuclear emergencies. Methods: Blood from four healthy donors was irradiated (0-5.00 Gy, Results: The automated dose-response curves for chromosome aberrations and micronuclei are Conclusion: This workflow provides a standardized, scalable, and reliable solution for rapid biodosimetry in mass-casualty radiological incidents, effectively bridging laboratory capacity and real-world emergency response needs.

Indexed as

biodosimetrycalibration curvecytokinesis-block micronucleus assaydicentric chromosomehigh-throughput automatedhigh-throughput scanning

Identifiers

PMID41890418

DOI10.1177/15593258261435382

PMCPMC13014006

What OpenQuestion holds

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LicenceCC BY-NC

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.