Comparative Analysis of Topical vs. Systemic Analgesics for Pain Control During Initial Orthodontic Alignment.

Background: Pain associated with the initial bonding of fixed appliances and archwire insertion is a primary cause of non-compliance and treatment discontinuation in orthodontics. While systemic non-steroidal anti-inflammatory drugs (NSAIDs) are the gold standard for pain management, they are associated with systemic side effects and potential inhibition of tooth movement. Topical anesthetics offer a localized alternative, but their comparative efficacy against systemic analgesics during the initial alignment phase remains understudied. Materials and Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted with 60 patients (mean age 16.4 ± 3.2 years) undergoing initial bonding with fixed appliances. Participants were randomly allocated into three groups ( Results: Pain peaked at 24 hours across all groups. At the 24-hour interval, Group A reported the lowest mean pain scores (24.5 ± 12.3 mm), followed by Group B (41.2 ± 15.6 mm) and Group C (62.8 ± 18.1 mm). The difference between Group A and B was statistically significant ( Conclusion: While systemic ibuprofen remains superior for managing deep periodontal pain associated with initial alignment, topical benzocaine provides significant pain reduction compared to placebo and serves as a viable alternative for patients contraindicated for systemic NSAIDs.