ReviewNeuro-oncology pediatrics2026
The potential and risks of FLASH radiotherapy in pediatric patients.
Review in Neuro-oncology pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Irradiation at ultra-high dose rates, also termed as 'FLASH' radiotherapy, has generated great interest in radiation oncology due to its potential to preferentially spare healthy tissue without compromising tumor control. Over the past decade, studies on the potential benefits of FLASH radiotherapy (FLASH-RT) have grown rapidly, yet the underlying mechanisms of this differential effect remain poorly understood. Nonetheless, compelling preclinical data, particularly the preservation of cognitive function after whole-brain irradiation, suggest that FLASH-RT may significantly improve quality of life, especially for pediatric patients. Early preclinical (large animal) and adult clinical trials are underway, prompting consideration of how and when to translate this modality to pediatric populations. This review summarizes the current state of FLASH-RT, with a special focus on pediatric CNS applications. We discuss disease-specific opportunities and limitations, how biological and clinical differences between adults and children may influence the FLASH effect, and key factors that must be evaluated before safe and effective pediatric translation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.