ArticleIBRO neuroscience reports2026
Glymphatic dysfunction is associated with cognitive impairment in white matter hyperintensities: A DTI-based study.
Article in IBRO neuroscience reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Glymphatic dysfunction as a potential mechanistic link to cognitive ımpairment in Behçet's disease: a hypothesis.Rheumatology international · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The underlying mechanisms of cognitive impairment in patients with white matter hyperintensities (WMHs) remain largely elusive. Glymphatic dysfunction, as measured by the diffusion tensor imaging along the perivascular space (DTI-ALPS) index, has been associated with cognitive decline across various neurological and psychiatric disorders. Objective: This study aims to examine the potential association between glymphatic dysfunction, as measured by the DTI-ALPS index, and cognitive impairment in patients with WMHs. Methods: A total of 88 patients with varying degrees of WMHs (Mild = 25, Moderate = 34, Severe = 29) and 32 matched healthy controls were recruited. Comprehensive neuropsychological assessments and MRI scans were performed on all participants. We compared demographic information, cognitive function, and DTI-ALPS indices between patients with WMHs and controls, and evaluated the correlation between cognitive impairment and the DTI-ALPS index. Results: Apart from hypertension, demographic characteristics were comparable across the four groups. Patients with WMHs showed significant impairments in emotional status, global function, language function, memory function, processing speed and cognitive flexibility. A reduction in Left_ALPS, Right_ALPS, and Mean_ALPS was observed in patients with WMHs, with these decreases significantly and negatively correlated with the WMHs volume (Left_ALPS, R = -0.381, Conclusion: Cognitive impairment in patients with WMHs is closely linked to decreased DTI-ALPS index, especially as white matter lesions worsen. Glymphatic dysfunction may play a critical role in this cognitive impairment, positioning the DTI-ALPS index may serve as a potential biomarker for cognitive impairment in patients with WMHs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.