ArticleBiochemistry and biophysics reports2026
A comparative study of dextran sodium sulfate-induced and spleen-kidney syndrome-based ulcerative colitis models.
Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Accurate animal models are essential for elucidating the pathogenesis of ulcerative colitis (UC). The widely used dextran sodium sulfate-induced UC (DSS-UC) model inadequately reflects the refractory nature of human UC. This study compared the traditional Chinese medicine (TCM)-based SKYD-UC model with the DSS-UC model to identify a more representative model. Methods: Network pharmacology was used to analyze the fundamental TCM syndrome of UC and to identify differential targets and pathways between DSS-UC and SKYD-UC. Both UC animal models were subsequently established, and body weight, organ indices, disease activity index (DAI) scores, colon length, mucosal damage, and serum biomarkers (IL-6, TNF-α, MPO, GSH-Px, GAS, and MTL) were evaluated. Results: Among the seven TCM syndromes, SKYD-UC presented the greatest number of targets and pathways, highlighting its fundamental importance. Specifically, 464 and 703 unique targets were identified for DSS-UC and SKYD-UC, respectively. DSS-UC unique targets were predominantly associated with inflammation, immune regulation, and cellular signaling. In contrast, SKYD-UC targets encompass a broader range of biological processes, including mitochondrial dysfunction, extracellular matrix remodeling, and pathways related to systemic UC complications. These findings were validated in animal experiments. Compared with the DSS-UC model, the SKYD-UC model demonstrated more severe damage, including pronounced spleen and thymus atrophy ( Conclusion: While both models reflect inflammation and immune dysregulation, the SKYD-UC model better simulates the refractory nature of UC, offering an effective animal model for UC research.
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