ArticleFrontiers in endocrinology2026
Assessment of the effects of whole-body muscle and fat mass on bone mineral content based on 628 DXA datasets.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The prevalence of osteoporosis is steadily increasing. Although the relationships between muscle mass, fat mass, and bone mineral content (BMC) have been extensively studied, they remain contentious. This study aimed to develop a unified statistical model to evaluate the independent effects of total muscle and fat mass on BMC, clarify their respective roles in osteoporosis pathogenesis, and inform targeted prevention strategies. Methods: We retrospectively analyzed data from 628 subjects who underwent body composition assessment at the Affiliated Hospital of Nanjing University of Chinese Medicine between January 2022 and July 2024. Collected parameters included age, height, weight, body mass index (BMI), total BMC, total muscle mass, total fat mass, and whole-body bone mineral density (BMD) T-scores. Groups were compared by sex, age and whole-body BMD T-score categories. Spearman correlation and multiple linear regression analyses were used to assess the associations of total BMC with total muscle and total fat mass. Results: Males had greater height, weight, BMI, total BMC, total muscle mass, and whole-body T-scores than females ( Conclusions: Muscle mass is the strongest and most consistent correlate of BMC. The role of fat is context-specific, varying by sex, age, and bone health. Based on current associative evidence, maintaining muscle may be considered a priority in bone health management, while fat's impact requires individualized assessment. Clinical Trial Registration: http://www.chictr.org.cn/ identifier ChiCTR2400085209.
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