Evidence map›Paper›PMID 41890131›Full record

ArticlebioRxiv : the preprint server for biology2026

Impaired motor activity in a CRISPR SCA5 L253P knock-in mouse is associated with selective β-III-spectrin subcellular redistribution in the cerebellum.

Adam W Avery, Brennon L O'Callaghan, Matthew T Thiel, Sarah A Denha, Devon G O'Callaghan, Emma M Cismas, Jared Lamp, Harry T Orr, Thomas S Hays

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Adam W AveryDepartment of Chemistry, Oakland University, Rochester, MI 48309, USA.ORCID 0000-0001-8085-1822
Brennon L O'CallaghanDepartment of Laboratory Medicine and Pathology, Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-0800-5856
Matthew T ThielDepartment of Chemistry, Oakland University, Rochester, MI 48309, USA.
Sarah A DenhaDepartment of Chemistry, Oakland University, Rochester, MI 48309, USA.ORCID 0000-0002-5341-5512
Devon G O'CallaghanDepartment of Laboratory Medicine and Pathology, Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0009-0005-2905-7726
Emma M CismasDepartment of Chemistry, Oakland University, Rochester, MI 48309, USA.ORCID 0009-0009-5070-6881
Jared LampIntegrated Mass Spectrometry Unit, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503, USA.ORCID 0000-0002-7187-7657
Harry T OrrDepartment of Laboratory Medicine and Pathology, Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-6118-741X
Thomas S HaysDepartment of Genetics and Cell Biology, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-4911-6042

Funding

STRUCTURE AND FUNCTION OF CYTOPLASMIC DYNEINR01GM044757 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HAYS, THOMAS S · 1990 to 2022
$5.7M
Molecular genetics of neurodegenerative pathogenic and protective pathways: The SCA1 perspectiveR35NS127248 · NINDS · UNIVERSITY OF MINNESOTA · PI Harry T. Orr · 2022 to 2026
$3.9M
Molecular and cellular mechanisms of spinocerebellar ataxia type 5R15NS116511 · NINDS · OAKLAND UNIVERSITY · PI AVERY, ADAM · 2020 to 2025
$903k
Structure and Function of Cytoplasmic DyneinR56GM044757 · NIGMS · UNIVERSITY OF MINNESOTA · PI HAYS, THOMAS S · 2008 to 2008
$490k
MINORITY PREDOCTORAL FELLOWSHIP PROGRAMF31NS011075 · NINDS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI ROMERO, DIANA H · 2000 to 2002
$47k
NIGMS NIH HHS R01 GM044757NIGMS NIH HHS R56 GM044757NINDS NIH HHS F31 NS011075NINDS NIH HHS R15 NS116511NINDS NIH HHS R35 NS127248
6 · The paper itself

Abstract

The spinocerebellar ataxia type 5 (SCA5) L253P mutation in β-III-spectrin causes high-affinity actin binding. Here we developed a CRISPR knock-in mouse to determine the i

Indexed as

actinneurodegenerationPurkinje neuronSCA5spectrinspinocerebellar ataxiaSPTBN2

Identifiers

PMID41890131
PMCPMC13015698

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.