Evidence map›Paper›PMID 41890103›Full record

ArticlebioRxiv : the preprint server for biology2026

Friedreich ataxia transcriptomic dysregulation and identification of cell type-specific biomarkers: A systematic review and meta-analysis.

Marnie L Maddock, Sara Miellet, Anjila Dongol, Amy J Hulme, Chloe K Kennedy, Louise A Corben, Rocio K Finol-Urdaneta, Alberto Nettel-Aguirre, Chiara Dionisi, Martin B Delatycki and 9 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Marnie L MaddockMolecular Horizons, School of Medical and Indigenous Health Sciences, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, New South Wales, Australia.ORCID 0000-0001-6393-4837
Sara MielletMolecular Horizons, School of Medical and Indigenous Health Sciences, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, New South Wales, Australia.ORCID 0000-0003-1400-9711
Anjila DongolMolecular Horizons, School of Medical and Indigenous Health Sciences, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, New South Wales, Australia.ORCID 0000-0003-3355-6585
Amy J HulmeMolecular Horizons, School of Medical and Indigenous Health Sciences, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, New South Wales, Australia.ORCID 0000-0001-7700-3486
Chloe K KennedyMolecular Horizons, School of Medical and Indigenous Health Sciences, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, New South Wales, Australia.ORCID 0009-0004-3795-8391
Louise A CorbenMurdoch Children's Research Institute, Parkville, Victoria, Australia.ORCID 0000-0001-8767-4582
Rocio K Finol-UrdanetaMolecular Horizons, School of Medical and Indigenous Health Sciences, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, New South Wales, Australia.ORCID 0000-0003-2157-4532
Alberto Nettel-AguirreSchool of Social Sciences, University of Wollongong, Wollongong, New South Wales, Australia.
Chiara DionisiSchool of Immunology and Microbial Sciences, King's College London, London, UK.ORCID 0009-0006-7908-4236
Martin B DelatyckiBruce Lefroy Centre, Murdoch Children's Research Institute, Victoria, Australia.
Joel M GottesfeldScripps Research Institute, La Jolla, California, USA.
Massimo PandolfoDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Elisabetta SoragniFriedreich's Ataxia Research Alliance, USA.ORCID 0009-0004-7473-7299
Sanjay I BidichandaniDepartment of Pediatrics, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma, USA.ORCID 0000-0001-6191-6475
Jarmon G LeesSt Vincent's Institute of Medical Research, Victoria, Australia.ORCID 0000-0002-9259-8657
Shiang Y LimSt Vincent's Institute of Medical Research, Victoria, Australia.ORCID 0000-0002-0442-3655
Jill S NapieralaDepartment of Neurology, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-5141-0822
Marek NapieralaDepartment of Neurology, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-9987-0641
Mirella DottoriMolecular Horizons, School of Medical and Indigenous Health Sciences, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, New South Wales, Australia.ORCID 0000-0003-0598-4195

Funding

RNA-induced transcriptional gene silencing in Friedreich ataxiaR01NS072418 · NINDS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI BIDICHANDANI, SANJAY I · 2010 to 2014
$1.2M
NINDS NIH HHS R01 NS072418
6 · The paper itself

Abstract

Friedreich ataxia (FRDA) is a progressive multisystem neurodegenerative disease mostly caused by a homozygous GAA repeat expansion in the

Indexed as

BiomarkersCardiomyocytesCell-type specificityFriedreich ataxiaMeta-analysisNeurodegenerative diseaseRNA sequencingSelective vulnerabilitySensory neuronsTranscriptomic atlas

Identifiers

PMID41890103
PMCPMC13015369

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.