Evidence map›Paper›PMID 41890101›Full record

ArticlebioRxiv : the preprint server for biology2026

Chronic cold exposure induces plasticity of mitochondrial calcium uptake in beige and brown fat of UCP1-deficient mice.

Casandra G Chamorro, Sachin Pathuri, Rebeca Acin-Perez, Michael Chhan, Madeleine G Milner, Natalia Ermolova, Anthony E Jones, Ajit S Divakaruni, Linsey Stiles, Andrea L Hevener and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Casandra G ChamorroDepartment of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Sachin PathuriDepartment of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Rebeca Acin-PerezDepartment of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Michael ChhanDepartment of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Madeleine G MilnerDepartment of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Natalia ErmolovaDepartment of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Anthony E JonesDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA.
Ajit S DivakaruniDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA.
Linsey StilesDepartment of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Andrea L HevenerDavid Geffen School of Medicine, Department of Medicine, Division of Endocrinology and Metabolism, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-2528-9651
Zhenqi ZhouDavid Geffen School of Medicine, Department of Medicine, Division of Endocrinology and Metabolism, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Orian S ShirihaiDepartment of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Yuriy KirichokWashU Medicine, Dept. of Biochemistry and Molecular Biophysics, 660 S. Euclid Ave., Box 8231, St. Louis, MO 63110.
Ambre M BertholetDepartment of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.

Funding

Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
Molecular Biophysics of Mitochondrial MembranesR35GM136415 · NIGMS · WASHINGTON UNIVERSITY · PI Yuriy Kirichok · 2020 to 2026
$4.7M
Understanding How Metabolic Cofactors Control Cell Function and FateR35GM138003 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Ajit Divakaruni · 2020 to 2026
$2.8M
Role of dynamin-related protein 1 in the regulation of metabolism and skeletal muscle massR01DK125354 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHOU, ZHENQI · 2021 to 2025
$2.5M
Mechanisms of regulation of mitochondrial H+ leak and thermogenesisR35GM143097 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BERTHOLET, AMBRE MARGUERITE SOLANGE · 2021 to 2025
$1.9M
NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK125354NIGMS NIH HHS R35 GM136415NIGMS NIH HHS R35 GM138003NIGMS NIH HHS R35 GM143097
6 · The paper itself

Abstract

Brown adipose tissue (BAT) is a unique tissue with mitochondria specialized for thermogenesis via the BAT-specific uncoupling protein 1 (UCP1).

Indexed as

brown adipose tissuecalciumcoldER–mitochondria tetheringMitochondrial thermogenesisUCP1

Identifiers

PMID41890101
PMCPMC13015561

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.