Evidence map›Paper›PMID 41890091›Full record

ArticlebioRxiv : the preprint server for biology2026

Female iPSC X-chromosome inactivation (XCI) erosion and its transcriptomic effects during CRISPR gene editing and neural differentiation.

Christina Thapa, Emily K Oh, David Sirkin, Jennifer Lahey, Sol Díaz de León Guerrerro, Ada McCarroll, Prarthana Gowda, Hanwen Zhang, Alexandra Barishman, Lilia Peyton and 9 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Christina ThapaCenter for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.ORCID 0000-0003-0822-2911
Emily K OhCenter for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.ORCID 0009-0002-6317-4473
David SirkinCenter for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.ORCID 0009-0005-9985-1052
Jennifer LaheyCenter for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.
Sol Díaz de León GuerrerroDepartment of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.ORCID 0000-0002-1457-8204
Ada McCarrollCenter for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.ORCID 0009-0000-3592-4463
Prarthana GowdaDepartment of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Hanwen ZhangCenter for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.ORCID 0000-0001-8490-918X
Alexandra BarishmanCenter for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.ORCID 0009-0007-2801-290X
Lilia PeytonCenter for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.ORCID 0009-0008-7860-0096
Siwei ZhangCenter for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.ORCID 0000-0002-1646-063X
Rebecca M PollakCenter for Advanced Biotechnology and Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.ORCID 0000-0002-0428-240X
Ronald P HartCenter for Advanced Biotechnology and Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.ORCID 0000-0003-4836-8712
Carlos N PatoDepartment of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Anat KreimerCenter for Advanced Biotechnology and Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.ORCID 0000-0002-3066-5498
Jennifer G MulleDepartment of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.ORCID 0000-0001-8593-8468
Alan R SandersCenter for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.ORCID 0000-0001-6629-4011
Zhiping PangDepartment of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.ORCID 0000-0002-6183-1233
Jubao DuanCenter for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.ORCID 0000-0002-7215-3220

Funding

Assay and Data Generation Center (ADGC) for the Model of iPSC-derived Neurons for NPD (MiNND)RM1MH133065 · NIMH · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Jubao Duan, Jennifer Gladys Mulle · 2023 to 2026
$7.0M
Systematic Functional Interpretation of Regulatory Variants in SchizophreniaR01MH106575 · NIMH · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI DUAN, JUBAO · 2016 to 2025
$6.1M
Deciphering the neural basis of alcohol use disorders using human and mouse neuronsR01AA023797 · NIAAA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ZHIPING P. PANG · 2016 to 2026
$4.8M
Modeling Alzheimer's disease genetic variants in hiPSCR01AG063175 · NIA · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI DUAN, JUBAO, THINAKARAN, GOPAL · 2019 to 2023
$3.7M
Loss-of-Function Analyses of SETD1A in Human Neural ModelsR01MH125528 · NIMH · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI MING, GUO-LI, PANG, ZHIPING P. · 2021 to 2025
$3.2M
Integrating epigenomics with DNA breathing dynamics for human non-coding disease variantsR01MH116281 · NIMH · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI ALEXANDROV, BOIAN STOIANOV, DUAN, JUBAO · 2019 to 2023
$3.0M
NIAAA NIH HHS R01 AA023797NIA NIH HHS R01 AG063175NIMH NIH HHS R01 MH106575NIMH NIH HHS R01 MH116281NIMH NIH HHS R01 MH125528NIMH NIH HHS RM1 MH133065
6 · The paper itself

Abstract

Human induced pluripotent stem cells (hiPSC) and iPSC-differentiated neural cells, in combination with CRISPR editing, are commonly used for studying neurodevelopmental and other brain disorders. Female iPSCs undergo random X-chromosome inactivation (XCI) via epigenetic silencing by noncoding

Indexed as

allele-specific expression (ASE)autosomalCRSIPR gene editingHuman pluripotent stem cells (hiPSC)neural differentiationneurodevelopmentX-chromosome inactivation (XCI)X-chromosome inactive specific transcript (XIST)XCI erosion

Identifiers

PMID41890091
PMCPMC13014181

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.