ArticlebioRxiv : the preprint server for biology2026
SUN2 mediates epigenetic remodeling to drive mechanotransduction during skin fibrosis.
Aya Nassereddine, Kerri Davidson, Sandra Sandria, Jyot D Antani, Shreyasi Das, Rachel Rivera, Van Anh Tran, Monique Hinchcliff, Megan King, Valerie Horsley
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Aya NassereddineDepartment of Molecular, Cellular and Developmental Biology, Yale University, United States.
Kerri DavidsonDepartment of Cell Biology, Yale School of Medicine, United States.
Sandra SandriaDepartment of Cell Biology, Yale School of Medicine, United States.
Jyot D AntaniDepartment of Ecology and Evolutionary Biology; Center for Phage Biology & Therapy; and Quantitative Biology Institute, Yale University, United States.ORCID 0000-0002-7402-983X Shreyasi DasDepartment of Biomedical Engineering, Yale University, United States.
Rachel RiveraCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, United States.
Van Anh TranPerelman School of Medicine at the University of Pennsylvania, United States.
Monique HinchcliffDepartment of Internal Medicine, Section of Rheumatology, Allergy & Immunology, Yale School of Medicine, United States.
Megan KingDepartment of Molecular, Cellular and Developmental Biology, Yale University, United States.ORCID 0000-0002-1688-2226 Valerie HorsleyDepartment of Molecular, Cellular and Developmental Biology, Yale University, United States.ORCID 0000-0002-1254-5839 Funding
Mechanism and Impact of Dermal adipocyte remodeling in skin fibrosisR01AR076938 · NIAMS · YALE UNIVERSITY · PI ATIT, RADHIKA P, HORSLEY, VALERIE · 2020 to 2024
$2.4MThe genetic and non-genetic responses of chromatin to forceR35GM153474 · NIGMS · YALE UNIVERSITY · PI MEGAN C KING · 2024 to 2026
$1.3MMetabolic regulation of inflammation during tissue repairR01AR084558 · NIAMS · YALE UNIVERSITY · PI Valerie Horsley, KATHRYN MILLER-JENSEN · 2025 to 2026
$956kPacific Bioscience Sequel II sequencing system for the Yale Center for Genome Analysis (YCGA)S10OD028669 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2020 to 2020
$407kDefining a mechanism for inner nuclear membrane protein SUN2's mechanical regulation of skin fibrosisF31AR085488 · NIAMS · YALE UNIVERSITY · PI SANDRIA, SANDRA DEL CARMEN · 2025 to 2025
$50kNIAMS NIH HHS F31 AR085488NIAMS NIH HHS R01 AR076938NIAMS NIH HHS R01 AR084558NIGMS NIH HHS R35 GM153474NIH HHS S10 OD028669
6 · The paper itselfAbstract
Fibrosis involves sustained changes in fibroblast gene expression, leading to excessive extracellular matrix (ECM) deposition and progressive tissue stiffening. Although matrix stiffness is a potent regulator of cell fate and transcription, it is not clear how nuclear mechanosensing contributes to fibrosis. Here, we define a central role for SUN2, a component of linker of nucleoskeleton and cytoskeleton (LINC) complexes, as a mediator of stiffness-dependent nuclear and chromatin responses during skin fibrosis.
Identifiers
PMID41890082
PMCPMC13015350
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