Evidence map›Paper›PMID 41890071›Full record

ArticlebioRxiv : the preprint server for biology2026

The pyruvate branch point controls lymphoid cancer cell dissemination.

Hamidullah Khan, Steven John, Sushmita Roy, Mohd Farhan, Nguyet Minh Hoang, Patrick Buethe, Aman Prasad, Aman Nihal, David T Yang, Lixin Rui and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hamidullah KhanDepartment of Dermatology, University of Wisconsin-Madison, Madison, WI 53705, USA.
Steven JohnMorgridge Institute for Research, Madison, Wisconsin, 53706 USA.
Sushmita RoyDepartment of Dermatology, University of Wisconsin-Madison, Madison, WI 53705, USA.
Mohd FarhanWashington DC VA Medical Center, Washington, DC 20422, USA.
Nguyet Minh HoangDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53792, USA.
Patrick BuetheDepartment of Dermatology, University of Wisconsin-Madison, Madison, WI 53705, USA.
Aman PrasadDepartment of Dermatology, University of Wisconsin-Madison, Madison, WI 53705, USA.
Aman NihalDepartment of Dermatology, University of Wisconsin-Madison, Madison, WI 53705, USA.
David T YangDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
Lixin RuiDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53792, USA.
Jing FanMorgridge Institute for Research, Madison, Wisconsin, 53706 USA.
Stefan M SchiekeDepartment of Dermatology, University of Wisconsin-Madison, Madison, WI 53705, USA.

Funding

Targeting EGR1 signaling pathways in diffuse large B cell lymphomaR01CA266354 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Lixin Rui · 2022 to 2026
$1.7M
CSRD VA I01 CX002240NCI NIH HHS R01 CA266354
6 · The paper itself

Abstract

Cancer cell dissemination critically determines clinical prognosis, yet metabolic dependencies and corresponding therapeutic targets during spread of lymphoid malignancies remain poorly understood. Here we show that the pyruvate branch point operates as a metabolic checkpoint for lymphoid cancer cell migration and disease dissemination through mitochondrial ROS (mROS)/HIF-1a signaling. Isolation of highly migratory mROS

Indexed as

lymphoid malignanciesmetabolic reprogrammingmitochondriapyruvateredox signalingTCA cycle

Identifiers

PMID41890071
PMCPMC13015709

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.