Evidence map›Paper›PMID 41890063›Full record

ArticlebioRxiv : the preprint server for biology2026

SNED1 fibrillar assembly in the extracellular matrix requires fibronectin and collagen I.

Leanna Leverton, Dharma Pally, Asantewaa Jones, Camille Therol, Sylvie Ricard-Blum, Alexandra Naba

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Leanna LevertonDepartment of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, 60612, U.S.A.
Dharma PallyDepartment of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, 60612, U.S.A.
Asantewaa JonesDepartment of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, 60612, U.S.A.
Camille TherolICBMS, UMR 5246 CNRS - Université Claude Bernard Lyon 1, Villeurbanne, F-69622, France.
Sylvie Ricard-BlumICBMS, UMR 5246 CNRS - Université Claude Bernard Lyon 1, Villeurbanne, F-69622, France.
Alexandra NabaDepartment of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, 60612, U.S.A.ORCID 0000-0002-4796-5614

Funding

Vascular Biology, Signaling and Therapeutics training programT32HL144459 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KITAJEWSKI, JAN K., WARY, KISHORE K · 2019 to 2023
$1.6M
Mechanisms guiding the fibrillar assembly of SNED1 in the extracellular matrixR01GM148423 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Alexandra Naba · 2023 to 2026
$1.2M
NHLBI NIH HHS T32 HL144459NIGMS NIH HHS R01 GM148423
6 · The paper itself

Abstract

The extracellular matrix (ECM) is a meshwork of proteins that orchestrates a broad range of cellular phenotypes, including proliferation, adhesion, migration, and differentiation. SNED1 is a newly characterized ECM glycoprotein that promotes cell adhesion and is essential for embryonic development. Its upregulation is also associated with breast cancer metastasis and poor prognosis for breast cancer patients. We recently showed that SNED1 assembles into fibrillar structures, but the mechanisms guiding its incorporation into the ECM scaffold remain unknown. Combining biochemical assays and confocal immunofluorescence imaging

Indexed as

Cell-derived matrixDecellularizationECM depositionFibrillogenesisProtein-protein interactions

Identifiers

PMID41890063
PMCPMC13015494

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.