Evidence map›Paper›PMID 41890061›Full record

ArticlebioRxiv : the preprint server for biology2026

The osteoclast intracellular environment fosters bacterial growth during

Luke D O'Connor, Saumya Bhagat, Nidhi Roghati, Gabriel Mbalaviele, James E Cassat, Deborah J Veis

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Luke D O'ConnorDivision of Bone & Mineral Diseases, Musculoskeletal Research Center, Washington University School of Medicine, Saint Louis, Missouri, USA.
Saumya BhagatDivision of Bone & Mineral Diseases, Musculoskeletal Research Center, Washington University School of Medicine, Saint Louis, Missouri, USA.
Nidhi RoghatiDivision of Bone & Mineral Diseases, Musculoskeletal Research Center, Washington University School of Medicine, Saint Louis, Missouri, USA.
Gabriel MbalavieleDivision of Bone & Mineral Diseases, Musculoskeletal Research Center, Washington University School of Medicine, Saint Louis, Missouri, USA.ORCID 0000-0003-4660-0952
James E CassatDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-1199-1167
Deborah J VeisDivision of Bone & Mineral Diseases, Musculoskeletal Research Center, Washington University School of Medicine, Saint Louis, Missouri, USA.ORCID 0000-0001-7101-5582

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
Washington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Alfred Hyoungju Kim · 2018 to 2026
$7.6M
Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
Training Program in Cellular and Molecular BiologyT32GM139774 · NIGMS · WASHINGTON UNIVERSITY · PI HEATHER L TRUE-KROB · 2021 to 2026
$6.7M
Skeletal Disorders Training ProgramT32AR060719 · NIAMS · WASHINGTON UNIVERSITY · PI Roberto Civitelli · 2011 to 2026
$4.6M
Differential Inflammasome Regulation in the pathogenesis of S. aureus osteomyelitisR01AI161022 · NIAID · WASHINGTON UNIVERSITY · PI CASSAT, JAMES E, MBALAVIELE, GABRIEL · 2021 to 2025
$3.4M
Fungal-bacterial dynamics driving dysregulated host responses and lethal synergismR01AI177615 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JAMES E CASSAT, PAUL L FIDEL · 2024 to 2026
$2.4M
Molecular pathways of calcium pyrophosphate deposition diseaseR01AG077732 · NIA · MEDICAL COLLEGE OF WISCONSIN · PI Gabriel Mbalaviele, Ann K Rosenthal · 2022 to 2026
$2.4M
Hepatic steatosis promotes liver metastasisR01CA258325 · NCI · WASHINGTON UNIVERSITY · PI Nidhi Rohatgi · 2022 to 2026
$2.3M
Mechanisms of antibiotic failure during osteomyelitisR01AI173795 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JAMES E CASSAT · 2023 to 2026
$2.2M
Antibiotic-based PET Imaging of Implant Associated Gram-positive Bacterial InfectionsR21EB034882 · NIBIB · WASHINGTON UNIVERSITY · PI THOREK, DANIEL LYNDON JAFFE · 2024 to 2024
$385k
NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA258325NIAID NIH HHS R01 AI161022NIAID NIH HHS R01 AI173795NIAID NIH HHS R01 AI177615NIAMS NIH HHS P30 AR073752NIAMS NIH HHS P30 AR074992NIAMS NIH HHS T32 AR060719NIA NIH HHS R01 AG077732NIBIB NIH HHS R21 EB034882NIDDK NIH HHS P30 DK020579NIGMS NIH HHS T32 GM139774
6 · The paper itself

Abstract

Bone infections, which are predominantly caused by

Identifiers

PMID41890061
PMCPMC13015422

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.