Evidence map›Paper›PMID 41890060›Full record

ArticlebioRxiv : the preprint server for biology2026

Single-library chromosome-scale diploid assemblies of vole genomes resolve a species-specific duplication implicated in pair bonding.

Mohamed Abuelanin, Gulhan Kaya, Juniper A Lake, Christine Lambert, Melody V Wu, Kristen M Berendzen, Ksenia Krasheninnikova, Jonathan M D Wood, Nancy G Solomon, Zoe R Donaldson and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Mohamed AbuelaninGenome Center, MIND Institute, and Department of Biochemistry & Molecular Medicine, University of California, Davis, CA 95616, USA.
Gulhan KayaGenome Center, MIND Institute, and Department of Biochemistry & Molecular Medicine, University of California, Davis, CA 95616, USA.
Juniper A LakePacific Biosciences, Menlo Park, CA 94025, USA.
Christine LambertPacific Biosciences, Menlo Park, CA 94025, USA.
Melody V WuCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Kristen M BerendzenDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Ksenia KrasheninnikovaWellcome Sanger Institute, Hinxton CB10 1SA, UK.
Jonathan M D WoodWellcome Sanger Institute, Hinxton CB10 1SA, UK.
Nancy G SolomonDepartment of Biology, Miami University of Ohio, Miami, OH, USA.
Zoe R DonaldsonDepartment of Molecular, Cellular, and Developmental Biology, Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.ORCID 0000-0001-6699-7905
Karen L BalesDepartments of Psychology; Neurobiology, Physiology, and Behavior; and California National Primate Research Center, University of California, Davis, Davis, CA, USA.
Kerstin HoweWellcome Sanger Institute, Hinxton CB10 1SA, UK.
Jonas KorlachPacific Biosciences, Menlo Park, CA 94025, USA.
Devanand ManoliDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-7238-2330
Jessica TollkuhnCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.ORCID 0000-0001-5991-7620
Megan Y DennisGenome Center, MIND Institute, and Department of Biochemistry & Molecular Medicine, University of California, Davis, CA 95616, USA.ORCID 0000-0002-8502-5420

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI David A Tuveson · 1987 to 2026
$118.9M
Understanding the neural basis of social attachmentR01MH123513 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MANOLI, DEVANAND SADANAND · 2020 to 2024
$3.3M
Neuronal basis of social motivation and the failure to adapt to lossDP2MH119427 · NIMH · UNIVERSITY OF COLORADO · PI DONALDSON, ZOE REBECCA · 2018 to 2019
$2.5M
Human gene duplications in neurodevelopment and diseaseRF1MH132818 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DENNIS, MEGAN Y · 2025 to 2025
$2.1M
Human gene duplications in neurodevelopment and diseaseR01MH132818 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DENNIS, MEGAN Y · 2023 to 2024
$1.4M
NCI NIH HHS P30 CA045508NIMH NIH HHS DP2 MH119427NIMH NIH HHS R01 MH123513NIMH NIH HHS R01 MH132818NIMH NIH HHS RF1 MH132818Wellcome Trust
6 · The paper itself

Abstract

High-quality reference genomes are essential to effectively characterize genomic drivers of speciation, phenotypic diversity, and disease causality. Larger complex genomes often require integration of long-read DNA sequencing with additional genomic data, such as chromosome conformation capture (Hi-C or CiFi) to generate phased chromosome-scale assemblies, however this requires multiple sequencing platforms (in the case of Hi-C) or the construction of multiple long-read sequencing libraries. Here, we devise a strategy that combines PacBio HiFi and CiFi sequencing in a single library and run to efficiently produce high-quality contiguous chromosome-scale diploid genome assemblies. We apply this approach to liver tissue from single individuals of prairie vole (

Indexed as

3CChromosome conformation captureCiFigenome assemblygenome scaffoldingHiFiLong-read sequencingmate-pair bondingmeadow voleprairie volevasopressin

Identifiers

PMID41890060
PMCPMC13015472

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.