Evidence map›Paper›PMID 41890046›Full record

ArticlebioRxiv : the preprint server for biology2026

CD8

Hao Hu, Peter Bor-Chian Lin, Carisa Zeng, Prabal Sharma, Yongyi Li, Hong Jiang, Jonathan Nulman, Ray A Ohara, Tong Wu, Shasha Li and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hao HuDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0003-3622-9897
Peter Bor-Chian LinDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.
Carisa ZengDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Prabal SharmaDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.
Yongyi LiDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.
Hong JiangDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.
Jonathan NulmanDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.
Ray A OharaDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Tong WuDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Shasha LiDivision of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Wayne M YokoyamaDivision of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Maxim N ArtyomovDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-1133-4212
Kenneth M MurphyDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-3505-9630
Jason D UlrichDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.
David M HoltzmanDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-3400-0856

Funding

Effect of APOE on CNS Neurons: Role of LRPRF1NS090934 · NINDS · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M. · 2020 to 2025
$6.5M
Natural Killer Cell Tolerance to SelfR01AI129545 · NIAID · WASHINGTON UNIVERSITY · PI Wayne M. Yokoyama · 2017 to 2026
$5.5M
Effect of APOE on CNS Neurons: Role of LRPR01NS090934 · NINDS · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M. · 2014 to 2018
$3.0M
Role of T cells in tau-mediated neurodegenerationR01AG085374 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN, Jason D Ulrich · 2024 to 2026
$2.2M
NIAID NIH HHS R01 AI129545NIA NIH HHS R01 AG085374NINDS NIH HHS R01 NS090934NINDS NIH HHS RF1 NS090934
6 · The paper itself

Abstract

There are changes in adaptive immunity in Alzheimer's disease (AD) and increases in activated CD8

Identifiers

PMID41890046
PMCPMC13014200

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.