Evidence map›Paper›PMID 41890003›Full record

ArticlebioRxiv : the preprint server for biology2026

Pharmacological METTL3 inhibition attenuates HIV-1 latency reversal in CD4

Tarun Mishra, Avary Edwards, Li Wu

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Tarun MishraDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0002-0968-5654
Avary EdwardsBiomedical Sciences Graduate Program, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.ORCID 0009-0009-0869-686X
Li WuDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0002-5468-2487

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman · 2000 to 2026
$70.0M
How SAMHD1 regulates HIV-1 innate immunity and viral gene expressionR01AI189220 · NIAID · UNIVERSITY OF IOWA · PI Li Wu · 2025 to 2026
$1.5M
Targeting HIV-1 RNA modifications in latently infected CD4+ T cells for therapeutic developmentR33AI169659 · NIAID · UNIVERSITY OF IOWA · PI Li Wu · 2025 to 2026
$1.5M
SAMHD1-mediated regulation of innate immunity during SARS-CoV-2 infectionR21AI181742 · NIAID · UNIVERSITY OF IOWA · PI Li Wu · 2025 to 2026
$422k
NCI NIH HHS P30 CA086862NIAID NIH HHS R01 AI189220NIAID NIH HHS R21 AI181742NIAID NIH HHS R33 AI169659
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CD4+ T cellsHIV-1latency reversalm6A modificationMETTL3 inhibitors

Identifiers

PMID41890003
PMCPMC13015480

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.