Evidence map›Paper›PMID 41889990›Full record

ArticlebioRxiv : the preprint server for biology2026

Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant

Kyong T Fam, Pavan Kumar Chodisetti, Zifei Wang, Joshua A Homer, Christopher J Smedley, Seiya Kitamura, Benjamin Silva, Yijun Xiong, Althea Hansel-Harris, Matthew Holcomb and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Kyong T FamDepartment of Immunology and Microbiology, Scripps Research; La Jolla, California 92037, United States.ORCID 0000-0002-4877-5679
Pavan Kumar ChodisettiDepartment of Immunology and Microbiology, Scripps Research; La Jolla, California 92037, United States.ORCID 0000-0002-4890-8531
Zifei WangCancer Center, Cold Spring Harbor Laboratory; Cold Spring Harbor, NY 11724, USA.ORCID 0000-0001-6835-695X
Joshua A HomerCancer Center, Cold Spring Harbor Laboratory; Cold Spring Harbor, NY 11724, USA.ORCID 0000-0002-7881-7761
Christopher J SmedleyLa Trobe Institute for Molecular Science, La Trobe University, Science Dr., Bundoora, Melbourne, VIC, 3086 Australia.ORCID 0000-0001-5110-2574
Seiya KitamuraDepartment of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California 92037, United States.ORCID 0000-0003-2453-849X
Benjamin SilvaDepartment of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California 92037, United States.ORCID 0009-0002-0693-566X
Yijun XiongDepartment of Chemistry, Scripps Research; La Jolla, California 92037, United States.ORCID 0000-0001-6348-9649
Althea Hansel-HarrisDepartment of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California 92037, United States.ORCID 0000-0001-7064-1119
Matthew HolcombDepartment of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California 92037, United States.ORCID 0000-0002-8409-4344
Simeon BabarindeDepartment of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California 92037, United States.ORCID 0000-0001-5603-4769
Adrianna M TurnerDepartment of Immunology and Microbiology, Scripps Research; La Jolla, California 92037, United States.ORCID 0009-0000-5840-7119
Daria Van TyneDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.ORCID 0000-0001-7284-0103
Ian A WilsonDepartment of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California 92037, United States.ORCID 0000-0002-6469-2419
Stefano ForliDepartment of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California 92037, United States.ORCID 0000-0002-5964-7111
Benjamin F CravattDepartment of Chemistry, Scripps Research; La Jolla, California 92037, United States.ORCID 0000-0001-5330-3492
Donghyun ParkDepartment of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California 92037, United States.ORCID 0000-0003-2048-6004
Dennis W WolanDepartment of Integrative Structural & Computational Biology, Scripps Research; La Jolla, California 92037, United States.ORCID 0000-0001-9879-8353
John E MosesCancer Center, Cold Spring Harbor Laboratory; Cold Spring Harbor, NY 11724, USA.ORCID 0000-0003-2162-3234
Howard C HangDepartment of Immunology and Microbiology, Scripps Research; La Jolla, California 92037, United States.ORCID 0000-0003-4053-5547

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI David A Tuveson · 1987 to 2026
$118.9M
Adaptation of vancomycin-resistant enterococci during bloodstream infectionR01AI165519 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VAN TYNE, DARIA N · 2022 to 2025
$3.0M
Modulation of host immunity with recombinant peptidoglycan hydrolasesR21AT012958 · NCCIH · SCRIPPS RESEARCH INSTITUTE, THE · PI HANG, HOWARD C · 2024 to 2024
$506k
NCCIH NIH HHS R21 AT012958NCI NIH HHS P30 CA045508NIAID NIH HHS R01 AI165519
6 · The paper itself

Abstract

Vancomycin-resistant

Identifiers

PMID41889990
PMCPMC13014144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.