ArticlebioRxiv : the preprint server for biology2026
DksA-Dependent Stringent Stress Response Drives Virulence and Gastrointestinal Persistence of
Md Maidul Islam, Robert L Beckman, Noah A Nutter, Juan D Valencia-Bacca, Giovanna E Hernandez, Renee M Fleeman, Karen M Haas, M Ammar Zafar
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors.
Md Maidul IslamDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Robert L BeckmanBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.
Noah A NutterDepartment of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC, USA.
Juan D Valencia-BaccaDepartment of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC, USA.
Giovanna E HernandezDepartment of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC, USA.
Renee M FleemanBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.ORCID 0000-0001-7103-461X Karen M HaasDepartment of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC, USA.ORCID 0000-0002-9951-1964 M Ammar ZafarDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-3737-0422 Funding
TRAINING PROGRAM IN IMMUNOLOGY AND PATHOGENESIST32AI007401 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Martha Ann Alexander-Miller · 1991 to 2026
$4.4MMechanisms of Klebsiella pneumoniae gastrointestinal colonizationR01AI173244 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ZAFAR, MUHAMMAD AMMAR · 2023 to 2025
$1.8MRefining our understanding of antimicrobial peptide mediated disruption of the Klebsiella pneumoniae capsuleR00AI163295 · NIAID · UNIVERSITY OF CENTRAL FLORIDA · PI FLEEMAN, RENEE · 2023 to 2025
$747kBiology of hypervirulent Klebsiella pneumoniae translocation from the gastrointestinal tractR21AI166642 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ZAFAR, MUHAMMAD AMMAR · 2022 to 2023
$426kRole of B cells in controlling Klebsiella pneumoniae associated disease statesR21AI178595 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HAAS, KAREN M, ZAFAR, MUHAMMAD AMMAR · 2023 to 2024
$426kNIAID NIH HHS R00 AI163295NIAID NIH HHS R01 AI173244NIAID NIH HHS R21 AI166642NIAID NIH HHS R21 AI178595NIAID NIH HHS T32 AI007401
6 · The paper itselfAbstract
Successful gastrointestinal colonization (GI) by bacterial pathogens requires adaptation to nutrient competition and host-derived stresses in the gut, with adaptation via the bacterial stringent stress response playing a critical role. Epidemiological data suggest that the GI tract serves as a reservoir from where
Indexed as
antibiotic resistancebiofilm formationDksAgut colonizationK. pneumoniaestringent stress responsetransmission
Identifiers
PMID41889989
PMCPMC13015322
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