Evidence map›Paper›PMID 41889987›Full record

ArticlebioRxiv : the preprint server for biology2026

Age determines NK cell fate and tissue compartmentalization to CMV infection.

Isaac J Jensen, Benjamin J Redenti, Steven B Wells, Joshua I Gray, Daniel P Caron, Donna L Farber

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Isaac J JensenDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032 USA.ORCID 0000-0002-3107-3961
Benjamin J RedentiDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032 USA.
Steven B WellsDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032 USA.
Joshua I GrayDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032 USA.
Daniel P CaronDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032 USA.
Donna L FarberDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032 USA.ORCID 0000-0001-8236-9183

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Parisa Tehranifar · 1985 to 2026
$115.3M
Modeling the ecology of tissue-resident T cellsU01AI150680 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FARBER, DONNA L., YATES, ANDREW · 2020 to 2024
$5.0M
Evolution of T cell immunity in blood and tissues over childhoodU01AI168634 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber · 2022 to 2026
$4.1M
Columbia University Graduate Training Program in Microbiology and ImmunologyT32AI106711 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Nicholas Arpaia, Uttiya Basu · 2014 to 2026
$2.1M
Training in Translational Immunology ResearchT32AI148099 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SYKES, MEGAN · 2020 to 2024
$1.4M
Five-laser Aurora spectral flow cytometerS10OD030282 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CREUSOT, REMI J · 2022 to 2022
$361k
NCI NIH HHS P30 CA013696NIAID NIH HHS T32 AI106711NIAID NIH HHS T32 AI148099NIAID NIH HHS U01 AI150680NIAID NIH HHS U01 AI168634NIH HHS S10 OD030282
6 · The paper itself

Abstract

Cytomegalovirus (CMV), a ubiquitous herpesvirus, establishes persistent infection that is controlled by both NK and CD8 T cells. While immunity to CMV is primarily studied in adult mice and humans, most individuals acquire CMV during the early years of life and virus-specific NK and T cell responses during this vulnerable life stage are understudied. Here, we show distinct responses by infant and adult NK cells to CMV infection in both mice and humans resulting from cell-intrinsic features and host T cell responses. Infant mice sustained higher viral loads compared to adults following MCMV infection and exhibited non-redundant requirements for NK cells. Infant MCMV-reactive (Ly49H

Indexed as

adaptive-like NK cellsHuman immunologyImmune MemoryInfant ImmunityNK cells

Identifiers

PMID41889987
PMCPMC13015448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.