Evidence map›Paper›PMID 41889985›Full record

ArticlebioRxiv : the preprint server for biology2026

Persistent vulnerability to heroin relapse across the adult lifespan in rats.

Rajtarun Madangopal, Olivia R Drake, Diana Q Pham, Veronica A Lennon, Sophia J Weber, Justine Lee, Adekemi Sobukunola, Ava R Holmes, Omodolapo Nurudeen, Yavin Shaham and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Rajtarun MadangopalBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.ORCID 0000-0001-6202-302X
Olivia R DrakeBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Diana Q PhamBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Veronica A LennonBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Sophia J WeberBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Justine LeeBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Adekemi SobukunolaBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Ava R HolmesBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Omodolapo NurudeenBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Yavin ShahamBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Bruce T HopeBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.

Funding

Neurobiology of relapse to heroin &cocaineZ01DA000434 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI SHAHAM, YAVIN · 2000 to 2008
$3.3M
Sensitized Neurons that Mediate Sensitized BehaviorZ01DA000467 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI HOPE, BRUCE · 2004 to 2008
$1.7M
DEPRESSION PRONE SMOKERS AND CIGARETTE CRAVINGK08DA000467 · NIDA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCCHARGUE, DENNIS E · 2000 to 2004
$535k
DRUG USE LIABILITY: INVESTIGATING COMPETING MODELSK01DA000434 · NIDA · WASHINGTON UNIVERSITY · PI RIDENOUR, TY A · 2000 to 2004
$535k
Intramural NIH HHS Z01 DA000434Intramural NIH HHS Z01 DA000467NIDA NIH HHS K01 DA000434NIDA NIH HHS K08 DA000467
6 · The paper itself

Abstract

Relapse to opioid use during abstinence is often triggered by drug-associated cues but the persistence of this effect across the lifespan is unknown. Using a rat model, we found that relapse provoked by heroin-predictive discriminative stimuli persisted for over one year of abstinence, suggesting enduring, potentially lifelong opioid relapse vulnerability.

Identifiers

PMID41889985
PMCPMC13015459

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.