ArticlebioRxiv : the preprint server for biology2026
Visible Light Optical Coherence Tomography Reveals Aging at the Retinal Pigment Epithelium-Bruch's Membrane Interface.
Ruoyu Meng, Rachel C Kenney, Moning Pan, Alok K Gupta, Yasha S Modi, Pooja Chauhan, Christine A Curcio, Vivek J Srinivasan
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Rachel C KenneyDepartments of Neurology and Population Health, NYU Grossman School of Medicine, New York, New York, USA 10016.
Moning PanNYU Tandon School of Engineering, Brooklyn, New York, USA 11201.
Alok K GuptaTech4Health Institute, NYU Grossman School of Medicine, Long Island City, New York, USA 11101.
Yasha S ModiDepartment of Ophthalmology, NYU Grossman School of Medicine, New York, New York, USA 10016.
Pooja ChauhanTech4Health Institute, NYU Grossman School of Medicine, Long Island City, New York, USA 11101.
Christine A CurcioDepartment of Ophthalmology, NYU Grossman School of Medicine, New York, New York, USA 10016.
Vivek J SrinivasanNYU Tandon School of Engineering, Brooklyn, New York, USA 11201.
Funding
TRD3: Data Analytics and Intelligent Systems (AI-ML-DL-Visualization)P41EB032840 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JINYI QI · 2022 to 2026
$6.7MAchieving specificity in imaging neurodegeneration with visible light Optical Coherence TomographyOT2OD038130 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BALCER, LAURA, SRINIVASAN, VIVEK JAY · 2024 to 2025
$4.8MTrue Sub-Micron Ocular Diagnostics with Visible Light Optical Coherence TomographyR01EY031469 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SRINIVASAN, VIVEK JAY · 2020 to 2023
$2.3MVisible-to-near-infrared spanning Optical Coherence Tomography for retinal imaging at the half-micron scaleR01EY036192 · NEI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Vivek Jay Srinivasan · 2025 to 2026
$1.3MCoherence engineering of a human brain interferometer to quantitatively and specifically measure cerebral blood flowR01EB035762 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Vivek Jay Srinivasan · 2025 to 2026
$1.3MNEI NIH HHS R01 EY031469NEI NIH HHS R01 EY036192NIBIB NIH HHS P41 EB032840NIBIB NIH HHS R01 EB035762NIH HHS OT2 OD038130
6 · The paper itselfAbstract
Landmark histological studies have shown that as the retina ages, lipids and other debris accumulate within Bruch's membrane (BM) and in spaces introduced between BM and the retinal pigment epithelium (RPE). These deposits grow with age, increasing the risk of age-related macular degeneration (AMD), the leading cause of irreversible vision loss for older adults globally. Current
Indexed as
AgingBruch’s membraneOptical Coherence TomographyPhotoreceptorPhysical Sciences (Engineering) and Biological Sciences (Medical Sciences)Retinal Pigment EpitheliumVisible light
Identifiers
PMID41889981
PMCPMC13015331
What OpenQuestion holds
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