Evidence map›Paper›PMID 41889973›Full record

ArticlebioRxiv : the preprint server for biology2026

Scavenger Cells Failure to Maintain Systemic RNA Homeostasis Causes Epigenetically Inherited Germline Tumors.

Itai Rieger, Yael Mor, Itamar Lev, Anat Nitzan, Charlotte Beata Kong, Sarit Anava, Hila Gingold, Ronen Zaidel-Bar, Oded Rechavi

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Itai RiegerDepartment of Neurobiology, Wise Faculty of Life Sciences & Sagol School of Neuroscience; Tel Aviv University, Tel Aviv, Israel.ORCID 0009-0000-9635-2147
Yael MorDepartment of Neurobiology, Wise Faculty of Life Sciences & Sagol School of Neuroscience; Tel Aviv University, Tel Aviv, Israel.
Itamar LevDepartment of Neurobiology, Wise Faculty of Life Sciences & Sagol School of Neuroscience; Tel Aviv University, Tel Aviv, Israel.ORCID 0000-0002-9100-5100
Anat NitzanGray School of Medical Sciences, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Charlotte Beata KongDepartment of Neurobiology, Wise Faculty of Life Sciences & Sagol School of Neuroscience; Tel Aviv University, Tel Aviv, Israel.
Sarit AnavaDepartment of Neurobiology, Wise Faculty of Life Sciences & Sagol School of Neuroscience; Tel Aviv University, Tel Aviv, Israel.ORCID 0009-0008-2084-7643
Hila GingoldDepartment of Neurobiology, Wise Faculty of Life Sciences & Sagol School of Neuroscience; Tel Aviv University, Tel Aviv, Israel.
Ronen Zaidel-BarGray School of Medical Sciences, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID 0000-0002-1374-5007
Oded RechaviDepartment of Neurobiology, Wise Faculty of Life Sciences & Sagol School of Neuroscience; Tel Aviv University, Tel Aviv, Israel.ORCID 0000-0001-6172-3024

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Temporary disruptions to epigenetic mechanisms can misroute development and permanently alter cell fate. In particular, it was recently shown that transient loss of Polycomb silencing in flies irreversibly reprograms cells toward cancer (Parreno et al. 2024). Whether somatic dysfunction in parents can create multi-generational heritable susceptibility to tumorigenesis is unknown. In eutelic organisms like

Identifiers

PMID41889973
PMCPMC13015398

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.