Evidence map›Paper›PMID 41889968›Full record

ArticlebioRxiv : the preprint server for biology2026

Three immunoregulatory signatures define non-productive HIV infection in CD4

Giacomo M Butta, Bremy Alburquerque, Charlotte Kearns, Yoav Hadas, Max W VanDyck, Susanna Scaglioni, Noah Peña, Hoi Tong Wong, Elizabeth Levendosky, Charles Gleason and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Giacomo M ButtaDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bremy AlburquerqueDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Charlotte KearnsDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yoav HadasDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Max W VanDyckDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Susanna ScaglioniDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Noah PeñaDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hoi Tong WongDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Elizabeth LevendoskyDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Charles GleasonDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Xiao LinDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lara ManganaroDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Dalila PintoDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lubbertus C F MulderDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Viviana SimonDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
TRAINING PROGRAM: MECHANISMS OF VIRUS-HOST INTERACTIONST32AI007647 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI Domenico Tortorella · 2000 to 2026
$11.5M
Determinants of HIV latency in CD4+ T lymphocytesR01AI179598 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Viviana A Simon · 2024 to 2026
$2.5M
HERV proteogenomics of narcotic-driven HIV latencyR61DA058294 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MULDER, LUBBERTUS C · 2023 to 2025
$2.2M
COVID and Translational Science supercomputer (CATS)S10OD030463 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2021 to 2021
$2.0M
NCATS NIH HHS UL1 TR004419NIAID NIH HHS R01 AI179598NIAID NIH HHS T32 AI007647NIDA NIH HHS R61 DA058294NIH HHS S10 OD030463
6 · The paper itself

Abstract

The persistent HIV reservoir constitutes the main obstacle to curing HIV/AIDS disease. Our understanding of how non-productive HIV infections are established in primary human CD4

Indexed as

CCL22CD4+ TSCMchemokinesHIV/AIDSHIV latencyHIV reservoirIDO1immunoregulationnon-productive infectionTregstryptophan

Identifiers

PMID41889968
PMCPMC13015425

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.