ArticlebioRxiv : the preprint server for biology2026
Optineurin is a gatekeeper of mitochondrial health and proteostasis in Alzheimer's disease vulnerable neurons.
Christina Tsagkogianni, Matteo Trivisonno, Johanna Sophie Willner, Carlos Garcia-Molinero, Yingyu Tang, Beatrice Mattina, Maria Latorre-Leal, Wei Wang, Jean-Pierre Roussarie, Patricia Rodriguez-Rodriguez
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Christina TsagkogianniDepartment of Neurobiology Care Sciences and Society, Karolinska Institute. Stockholm, Sweden.
Matteo TrivisonnoDepartment of Neurobiology Care Sciences and Society, Karolinska Institute. Stockholm, Sweden.
Johanna Sophie WillnerDepartment of Neurobiology Care Sciences and Society, Karolinska Institute. Stockholm, Sweden.
Carlos Garcia-MolineroDepartment of Neurobiology Care Sciences and Society, Karolinska Institute. Stockholm, Sweden.
Yingyu TangDepartment of Neurobiology Care Sciences and Society, Karolinska Institute. Stockholm, Sweden.
Beatrice MattinaDepartment of Neurobiology Care Sciences and Society, Karolinska Institute. Stockholm, Sweden.
Maria Latorre-LealDepartment of Neurobiology Care Sciences and Society, Karolinska Institute. Stockholm, Sweden.
Wei WangBioinformatics Resource Center, The Rockefeller University. New York, NY, USA.
Jean-Pierre RoussarieBoston University Chobanian & Avedisian School of Medicine. Boston, MA, USA.
Patricia Rodriguez-RodriguezDepartment of Neurobiology Care Sciences and Society, Karolinska Institute. Stockholm, Sweden.ORCID 0000-0002-2438-3515 Funding
Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3MDeveloping, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6MSELECTIVE CELL VULNERABILITY IN ALZHEIMERS DISEASE (AG09464-21A1 PROJ4)RF1AG047779 · NIA · ROCKEFELLER UNIVERSITY · PI ROUSSARIE, JEAN-PIERRE · 2014 to 2014
$2.0MIdentification of early transcriptional and pathological changes undergone by vulnerable brain regions during prodromal Alzheimer's diseaseR21AG085464 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROUSSARIE, JEAN-PIERRE · 2024 to 2024
$459kNCATS NIH HHS UL1 TR001430NCATS NIH HHS UL1 TR001866NIA NIH HHS R21 AG085464NIA NIH HHS RF1 AG047779
6 · The paper itselfAbstract
Alterations in autophagy-related pathways and in mitochondrial function have long been associated with the pathology of several neurodegenerative disorders, including Alzheimer's disease (AD). However, the cascade of events that links these processes and how they contribute to the early degeneration of specific neuronal subpopulations remain to be understood. Here, we use a data-driven approach and identify
Indexed as
Alzheimeramyloid pathologymitophagyselective vulnerabilitytau pathology
Identifiers
PMID41889952
PMCPMC13015401
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